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Thomas Michael Braschler

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Related publications (45)

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Microfluidic sensor and method for obtaining such a sensor

Jonas Choppe, Niklas Van Neyghem, Philippe Renaud, Thomas Michael Braschler, David Vincent Bonzon, Georges Muller, Marc Lany, Luc Gaëtan Aeberli

The invention describes a method for producing hybrid microelectronic/microfluidic sensors at industrial scale. The method is characterized in that it comprises the following steps for obtaining said microfluidic channel: a) a first lamination step of a dr ...

2018

Dielectrophoretic sorting on a microfabricated flow cytometer: Label free separation of Babesia bovis infected erythrocytes

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre

Dielectrophoresis is a method that has demonstrated great potential in cell discrimination and isolation. In this study, the dielectrophoretic sorting of normal and Babesia bovis infected erythrocytes was performed using a microfabricated flow cytometer. S ...

2008

Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

Philippe Renaud, Arnaud Bertsch, Thomas Michael Braschler, Ariane Rochat, Amélie Barbara Hildegarde Béduer, Ludovic Serex

Cryogels are macroporous materials that display remarkable properties, such as high pore interconnection, large surface to volume ratio, and high mechanical stability, making them good candidates for 3D cell culture. However, shaping cryogels remains chall ...

Wiley2018

Injectable cryogel-based whole-cell cancer vaccines

Thomas Michael Braschler

A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we ...

Nature Publishing Group2015

Characterization and optimization of liquid electrodes for lateral dielectrophoresis

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel, Nicolas Demierre, Olof Pontus Linderholm, Urban Seger

Using the concept of insulator-based "electrodeless" dielectrophoresis, we present a novel geometry for shaping electric fields to achieve lateral deviation of particles in liquid flows. The field is generated by lateral planar metal electrodes and is guid ...

2007

An injectable, scalable, 3D tissue-engineered model of bone marrow adipogenesis and hematopoiesis

Thomas Michael Braschler, Olaia Maria Naveiras Torres-Quiroga, Martina Genta

E M H SWISS MEDICAL PUBLISHERS LTD2020

Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Philippe Renaud, Niccolo Piacentini, Thomas Michael Braschler

We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellul ...

2018

Sequential build-up of hydrogel environments around single cells

Philippe Renaud, Thomas Michael Braschler, Ana Valero, Anja Kunze, Ludovica Colella

Controlling alginate gel formation by diffusion of Ca ions through a filter barrier, a layer-by-layer deposition technique with resolution on the size scale of a single cell is presented. It gives the possibility of exposing cells under biocompatible condi ...

2009

High-Fidelity Printing Strategies for Printing 3D Vascular Hydrogel Structures

Jürgen Brugger, Philippe Renaud, Matthias Lütolf, Thomas Michael Braschler, Kristopher Pataky

Vascularization arguably poses the most significant hurdle for the success of most biomaterials-based tissue engineering therapies. In this work, we report two printing strategies that permit the 3D Inkjet printing of fluorescent alginate hydro gels into o ...

Soc Imaging Science & Technology, 7003 Kilworth Lane, Springfield, Va 22151 Usa2009

Shapeable scaffold material and uses thereof

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material imp ...

2017

Particle suitable for the manufacture of an implantable soft tissue engineering material

Philippe Renaud, Thomas Michael Braschler, Amélie Barbara Hildegarde Béduer

The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompati ...

2019

Wide channel dielectrophoresis-based particle exchanger with electrophoretic diffusion compensation

Philippe Renaud, Thomas Michael Braschler

We present here a microfluidic device for the chemical modification of particles. In order to alleviate diffusive mixing issues beads are pushed from a starting buffer to a reagent over a wide channel by an array of shifted electrodes. We also show that th ...

2009

A virtual valve for smooth contamination-free flow switching

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel, Nicolas Demierre, Anja Kunze, Mario Schlund

We present a channel geometry that allows for clean switching between different inlets of a microchip without any contamination of the inlets or the downstream flow. We drive this virtual valve with a pneumatic pressure setup that minimizes disturbance of ...

2007

Biochip with E. coli bacteria for detection of arsenic in drinking water

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel

Arsenic and other pollutants are often present in trace amounts in drinking water in a number of countries. In aqueous solutions the sensitivity of arsenic- responsive bacterial bioreporters is far better than the performance of chemical field test kits. H ...

Elsevier2009

Device and process for tissue-engineering and regenerative medicine

Thomas Michael Braschler, Olaia Maria Naveiras Torres-Quiroga, Josefine Catharina Pedersen Tratwal, Amélie Barbara Hildegarde Béduer, Martina Genta, Daniel Naveed Tavakol

A process and device for direct in-vitro to in-vivo transfer of a living microcarrier culture by controlled dehydration into a viscoelastic material capable of cell-protection during delivery. One particular purpose of the present invention is that of prov ...

2021

Continuous separation of cells by balanced dielectrophoretic forces at multiple frequencies

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre

We present a particle-sorting device based on the opposition of dielectrophoretic forces. The forces are generated by an array of electrode chambers located in both sidewalls of a main flow channel. Particles with different dielectric response perceive dif ...

2008

Biochip with E-Coli bacteria for detection of arsenic in drinking water

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel

Arsenic and other pollutants are often present in trace amounts in drinking water in a number of countries. In aqueous solutions the sensitivity of arsenic-responsive bacterial bioreporters is far better than the performance of chemical field test kits. Ho ...

2009

Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles

Philippe Renaud, Jeffrey Alan Hubbell, Heinrich Hofmann, Thomas Michael Braschler, Nicolas Demierre, Benedikt Steitz, Andrija Finka

We present a microfluidic device where micro- and nanoparticles can be continuously functionalized in flow. This device relies on an element called particle exchanger, which allows for particles to be taken from one medium and exposed to some reagent while ...

2008

A simple pneumatic setup for driving microfluidics

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel, Nicolas Demierre, Lynda Metref

2007

Continuous separation of cells in a microfluidic device using lateral dielectrophoresis

Philippe Renaud, Thomas Michael Braschler, Nicolas Demierre

2007