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Boris Hinz

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Related publications (27)

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Biocompatibility of bioresorbable poly(L-lactic acid) composite scaffolds obtained by supercritical gas foaming with human fetal bone cells

Jan-Anders Edvin Maansson, Dominique Pioletti, Pierre-Etienne Bourban, Boris Hinz, Laurence Marcelle Monique Rivier

The aim of this investigation was to test the biocompatibility of three-dimensional bioresorbable foams made of poly(L-lactic acid) (PLA), alone or filled with hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP), with human primary osteoblasts, usi ...

2005

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts

Melody Swartz, Boris Hinz

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how ...

American Association for Cancer Research2011

The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts

Boris Hinz

Surface properties of implanted biomaterials can cause fibrotic tissue reactions by stimulating differentiation of host fibroblasts into contractile myofibroblasts. Silk fibroin (SF) protein has been used as biomaterial in pure and blended form. however, i ...

Elsevier2008

The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function

Boris Hinz, Jean-Jacques Meister, Josiane Angèle Charlotte Smith-Clerc, Lara Buscemi Estefanell

Changes in the mechanical properties of dermis occur during skin aging or tissue remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic culture substrates that reproduce the variable softness of dermis, we determined ...

Nature Publishing Group2014

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

Boris Hinz, Jean-Jacques Meister

The conjunctive presence of mechanical stress and active transforming growth factor beta1 (TGF-beta1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts a ...

Rockefeller University Press2007

Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission

Boris Hinz

Fibroblast-to-myofibroblast differentiation - a key event in the development of fibrocontractive diseases and in wound granulation tissue contraction - is hallmarked by the formation of stress fibers and the neo-expression of alpha-smooth muscle actin. Inc ...

Elsevier2006

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

Boris Hinz

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibr ...

Nature Publishing Group2007

The Single-Molecule Mechanics of the Latent TGF-beta 1 Complex

Boris Hinz, Jean-Jacques Meister, Josiane Angèle Charlotte Smith-Clerc, Lara Buscemi Estefanell, Aurélie Formey de Saint Louvent

Background: TGF-beta 1 controls many pathophysiological processes including tissue homeostasis, fibrosis, and cancer progression. Together with its latency-associated peptide (LAP), TGF-beta 1 binds to the latent TGF-beta 1-binding protein-1 (LTBP-1), whic ...

Elsevier2011

A New Lock-step Mechanism of Matrix Remodelling Based on Subcellular Contractile Events

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell, Lysianne Follonier Castella

Myofibroblasts promote tissue contractures during fibrotic diseases. To understand how spontaneous changes in the intracellular calcium concentration, Ca2+, contribute to myofibroblast contraction, we analysed both Ca2+ and subcellular contractio ...

Company of Biologists2010

Wound-healing defect of CD18(-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation

Boris Hinz

We studied the mechanisms underlying the severely impaired wound healing associated with human leukocyte-adhesion deficiency syndrome-1 (LAD1) using a murine disease model. In CD18(-/-) mice, healing of full-thickness wounds was severely delayed during gra ...

Nature Publishing Group2005

Triplet imaging of oxygen consumption during the contraction of a single smooth muscle cell (A7r5)

Dimitri Nestor Alice Van De Ville, Theo Lasser, Kai Johnsson, Marcel Leutenegger, Iwan Märki, Boris Hinz, Aurélie Formey de Saint Louvent, Thiemo Spielmann, Matthias Geissbühler

Triplet imaging is a novel optical technique that allows investigating oxy- gen metabolism at the single cell and the sub-cellular level. The method combines high temporal and spatial resolution, which are required for the monitoring of fast kinetics of ox ...

Springer Science+Business Media2012

Myofibroblast communication is controlled by intercellular mechanical coupling

Boris Hinz, Jean-Jacques Meister, Sébastien Schaub, Lysianne Follonier Castella

Neoformation of intercellular adherens junctions accompanies the differentiation of fibroblasts into contractile myofibroblasts, a key event during development of fibrosis and in wound healing. We have previously shown that intercellular mechanical couplin ...

Company of Biologists2008

Hypoxia Impairs Skin Myofibroblast Differentiation and Function

Boris Hinz

Ischemic wounds are characterized by oxygen levels lower than that of healthy skin ( hypoxia) and poor healing. To better understand the pathophysiology of impaired wound healing, we investigated how switching from high ( 21%) to low ( 2%) oxygen levels di ...

Nature Publishing Group2010

Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity

Boris Hinz

During wound healing and fibrocontractive diseases fibroblasts acquire a smooth muscle cell-like phenotype by differentiating into contractile force generating myofibroblasts. We examined whether regulation of myofibroblast contraction in granulation tissu ...

Wiley-Blackwell2006

Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship

Boris Hinz

Integrins are crucial for the ability of cells to sense mechanical perturbations and to transmit intracellular stress to their environment. We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming g ...

Elsevier2008

Myofibroblasts work best under stress

Boris Hinz

Myofibroblasts are reparative connective tissue cells that contribute to the reconstruction of injured tissue by secreting new extracellular matrix and by exerting high contractile force. Deregulation of these activities results in tissue contracture and d ...

Elsevier2009

The myofibroblast: one function, multiple origins

Boris Hinz

The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production by this cell have been amply clarified. This review disc ...

American Society for Investigative Pathology2007

The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications

Boris Hinz, Jean-Jacques Meister, Lara Buscemi Estefanell

Strain devices with expandable polydimethylsiloxane (PDMS) culture membranes are frequently used to stretch cells in vitro, mimicking mechanically dynamic tissue environments. To immobilize cell-adhesive molecules to the otherwise non-adhesive PDMS substra ...

Elsevier2009

Lkb1 is required for TGFβ-mediated myofibroblast differentiation

Boris Hinz

Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component. Recently, it was noted that PJS-typ ...

Company of Biologists2008