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Christophe Roussel

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Related publications (34)

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Immobilized pH Gradient Gel Cell To Study the pH Dependence of Drug Lipophilicity

Hubert Girault, Christophe Roussel, Hoang-Trang Lam

An experimental setup to study the pH dependence of standard ion-transfer potentials at the water/NPOE interface is presented. The system is composed of a micro-hole generated by laser photoablation in a 12-μm polyethylene terephthalate film, the aqueous p ...

2006

Electrochemical Overhauser dynamic nuclear polarization

Jean-Philippe Ansermet, Christophe Roussel, Jonas Milani, Mika Antero Tamski

Nuclear Magnetic Resonance (NMR) spectroscopy suffers from low sensitivity due to the low nuclear spin polarization obtained within practically achievable external magnetic fields. Dynamic Nuclear Polarization (DNP) refers to techniques that increase the N ...

2020

Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode

Christophe Roussel

The anodic oxidation of polar amino acids (L-serine, L-threonine, L-asparagine, and L-glutamine) in aqueous electrolyte on smooth platinum electrode was carried out by cyclic voltammetry coupled to electrochemical quartz crystal microbalance (EQCM). pH (zw ...

Elsevier2017

About the Electrospray Ionization Source in Mass Spectrometry: Electrochemistry and On-chip Reactions

Hubert Girault, Joël Stéphane Rossier, Christophe Roussel, Niels Erik Lion, Bin Su, Manuel Alejandro Méndez Agudelo, Michel Prudent

The present work shows that the electrochemical properties of electrospray ionization (ESI) can be used to add functions to the process. As example, we show how the choice of the electrode material can be used to study interactions between metal ions and b ...

2009

Preparation, kinetics, mechanism and properties of semi-transparent photocatalytic stable films active in dye degradation

César Pulgarin, Juan Kiwi, Christophe Roussel, Laura Victoria Suárez Murillo

The photocatalytic activity, mechanism and characterization of polyethylene-TiO2 films (PE-TiO2) during the discoloration/degradation of methylene blue (MB) are reported in this study. PE-TiO2 films were prepared at moderate temperatures (similar to 90 deg ...

Elsevier2016

Optimization of a Py-GC/MS method for silicone -based lubricants analysis

Christophe Roussel

Condom evidence can be analysed using several analytical techniques, such as FTIR, MALDI-MS or DART-TOF-MS, but the only one that was used on real samples for transfer and persistence studies in the context of sexual assault or rape cases was Py-GC/MS. How ...

2020

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Arnaud Comment, Tian Cheng, Mor-Miri Mishkovsky, Najat Salameh, Christophe Roussel, Andrea Capozzi, Yuhei Takado, Jean-Noël Hyacinthe, Tim Rolf Eichhorn

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in v ...

National Academy of Sciences2013

Protoporphyrin IX sensitized titanium oxide gel electrode

Hubert Girault, Christophe Roussel, Bin Su

Titanium oxide (Ti(O)) xerogel films functionalized by protoporphyrin IX (PPIX) and ferrocene carboxylic acid (FCA) were deposited on indium tin oxide (ITO) electrodes following a sol–gel synthesis. PPIX and FCA were first complexed to titanium oxide precu ...

Elsevier2008

Salt Removal During Off-GelTM Electrophoresis of Protein Samples

Hubert Girault, Christophe Roussel, Niels Erik Lion

The Off-Gel™ technology was recently described for protein fractionation in a solution placed on top of an immobilized pH gradient gel. In addition, this process was found to remove salts from the biological samples to analyze. This desalting effect is stu ...

2005

Spin-dependent charge transfer at chiral electrodes probed by magnetic resonance

Jean-Philippe Ansermet, Christophe Roussel, Mika Antero Tamski, Felix Blumenschein

Chirality-induced spin selectivity is evidenced by exciting the spin resonance of radicals in an electrochemical cell where the working electrode is covered with a chiral self-assembled monolayer. Because the electron transfer to and from the paramagnetic ...

ROYAL SOC CHEMISTRY2020

RF-plasma pretreatment of surfaces leading to TiO2 coatings with improved optical absorption and OH-radical production

César Pulgarin, Juan Kiwi, Sami Rtimi, Christophe Roussel

Evidence is presented for the RF pretreatment of polyester enhances the TiO2 coating generation of oxidative species/radicals under a low level actinic light irradiation. After 30 min RF-plasma pretreatment of the polyester samples, the fastest bacterial i ...

Elsevier2013

Photocatalytic discoloration of aqueous malachite green solutions by UV-illuminated TiO2 nanoparticles under air and nitrogen atmospheres: effects of counter-ions and pH

César Pulgarin, Christophe Roussel

Under air atmosphere, the photocatalytic discoloration of malachite green (MG) aqueous solutions (a triphenylmethane dye) in the presence of TiO2 and UV light followed an oxidative pathway, involving an N-demethylation process evidenced by a blue shifting ...

2011

Probing charge transfer processes at p-GaAs electrodes under weak optical excitation

Jean-Philippe Ansermet, Christophe Roussel, Mika Antero Tamski, Felix Blumenschein

The p-GaAs photocathode/acetonitrile interface was characterised in the dark and with tens of mu W/cm(2) laser powers at 830 nm wavelength, using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Two redox mediators were used that p ...

2019

Plate for matrix-assisted laser desorption ionization mass spectrometry for, e.g. analyzing peptide, has substrate that is covered with light sensitive matrix with light absorber, charge carrier, probe molecule and photo-sensitizer

Hubert Girault, Liang Qiao, Christophe Roussel, Niels Erik Lion

NOVELTY - The plate has electrically conductive substrate (1) that is covered with light sensitive matrix (2). The matrix comprises light absorber, charge carrier, probe molecule and photo-sensitizer (3) arranged to oxidize probe molecule by irradiation of ...

2008

On-Line Counting of Cysteine Residues in Peptides during Electrospray Ionization by Electrogenerated Tags and Their Application to Protein Identification

Hubert Girault, Christophe Roussel, Niels Erik Lion, Michel Prudent, Loïc Dayon

The electrochemically induced mass spectrometric tagging of cysteines by substituted hydroquinones was studied for peptides in a classical electrospray solvent (i.e., MeOH/H2O/AcOH 50/49/1). The tagging efficiency was tested with different hydroquinone com ...

2005

Probing Cysteine Reactivity in Proteins by Mass Spectrometric EC-Tagging

Hubert Girault, Christophe Roussel, Loïc Dayon

The on-line electrochemical tagging (EC-tagging) of cysteine residues in proteins during mass spectrometry is studied to probe the cysteine environment. Benzoquinone probes electrogenerated at a microspray electrode react with the thiol functions of the pr ...

American Chemical Society2006

Blatter-type radicals as polarizing agents for electrochemical overhauser dynamic nuclear polarization

Jean-Philippe Ansermet, Holger Frauenrath, Christophe Roussel, Jonas Milani, Mika Antero Tamski, Felipe Andres Saenz Padilla

Overhauser dynamic nuclear polarization (O-DNP) refers to a microwave-assisted process where an unpaired electron's (e.g. a radical) spin polarization is transferred to surrounding nuclei in solution, thus increasing the nuclear magnetic resonance (NMR) si ...

Royal Society of Chemistry2022

Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates

Tian Cheng, Arnaud Comment, Giovanni Boero, Christophe Roussel, Andrea Capozzi

Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relativel ...

Nature Publishing Group2017

Plate for matrix-assisted laser desorption ionization mass spectrometry, comprises electroconductive substrate covered with sintered nanoparticles, deposited as array of spots, for supporting ionization of sorbed sample molecules

Hubert Girault, Liang Qiao, Christophe Roussel, Niels Erik Lion, Michel Prudent

NOVELTY - A plate comprises an electroconductive substrate (1) at least partially covered with sintered nanoparticles (2), deposited as an array of individual spots, for use as a sorbing phase for a sample, and for supporting ionization of sorbed sample mo ...

2009

Heterogeneous Overhauser-DNP on H-1 dominated by scalar coupling in aqueous solution

Jean-Philippe Ansermet, Christophe Roussel, Jonas Milani, Felipe Andres Saenz Padilla

The Overhauser Dynamic Nuclear Polarization (O-DNP) of H-1 nuclei usually involves a dipolar coupling with the polarizing agent, whereas scalar coupling via hyperfine interactions are more common with C-13 nuclei. Here, we show a scalar-coupling dominated ...

WILEY2022