Publications by Lukas Kappenberger

Related publications (22)

Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Jean-Marc Vesin, Vincent Jacquemet, Lukas Kappenberger, Laurent Renaud Uldry

Due to their transient nature, spontaneous terminations of atrial fibrillation (AF) are difficult to investigate. Apparently, confounding experimental findings about the time scale of this phenomenon have been reported, with values ranging from 1 s to 1 mi ...

Springer-Verlag2012

Full Spectral Analysis of the Atrial Components in the ECG during Atrial Fibrillation

Mathieu Lemay, Lukas Kappenberger

Clinical standard 12-lead ECG recordings over 5 minutes on patients in atrial fibrillation or in atrial flutter were analyzed. After suppression of the signal components related to ventricular activity, the amplitude spectra of all leads were inspected. Th ...

IEEE2008

Novel complexity measurements in the ECG differentiate persistent from permanent atrial fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry, Jérôme Sébastien Van Zaen

Purpose: Distinguishing persistent from permanent atrial fibrillation (AF) in a reliable way would improve AF patient management, as cardioversion options could be considered appropriately. In this study, complexity measures based on the combined analysis ...

2011

Harmonic frequency tracking algorithm for predicting the success of pharmacological cardioversion of atrial fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry, Andréa Buttu, Jérôme Sébastien Van Zaen

Purpose: Non-invasively predicting the success of pharmacological cardioversion for patients with atrial fibrillation (AF) would be of great interest in clinical settings. In this study, an adaptive algorithm for tracking fundamental and harmonic component ...

2011

Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry, Jérôme Sébastien Van Zaen, Yann Prudat

This study presents an automatic diagnostic method for the discrimination between persistent and long-standing atrial fibrillation (AF) based on the surface electrocardiogram (ECG). Standard 12-lead ECG recordings were acquired in 53 patients with either p ...

Oxford Univ Press2012

Susceptibility to Paroxysmal Atrial Fibrillation: A Study using Sinus Rhythm P Wave Parameters

Jean-Marc Vesin, Lukas Kappenberger, Lam Dang

Early recognition of patients at high risk for atrial fibrillation may help to minimize potential health risks. The detection of susceptibility to develop atrial fibrillation is thus a real clinical challenge. Whereas many studies have used the signal-aver ...

2010

Usefulness of P-Wave Duration and Morphologic Variability to Identify Patients Prone to Paroxysmal Atrial Fibrillation

Jean-Marc Vesin, Lukas Kappenberger, Sasan Yazdani, Adrian Luca

Few data are available on the assessment of P-wave beat-to-beat morphology variability and its ability to identify patients prone to paroxysmal atrial fibrillation (AF) occurrence. Aim of this study was to determine whether electrocardiographic (ECG) param ...

Excerpta Medica Inc-Elsevier Science Inc2017

Atrial septal pacing for the termination of atrial fibrillation: study in a biophysical model of human atria

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry

Aims While successful termination by pacing of organized atrial tachycardias has been observed in patients, single site rapid pacing has not yet led to conclusive results for the termination of atrial fibrillation (AF). The purpose of this study was to eva ...

Oxford Univ Press2012

The Role of Atrial Modeling in the Development of ECG Processing Tools

Jean-Marc Vesin, Vincent Jacquemet, Mathieu Lemay, Lukas Kappenberger, Laurent Renaud Uldry, Cédric Duchene

The standard ECG remains the most common non-invasive tool for assessing atrial fibrillation. Specific signal processing techniques have been developed to improve the diagnosis. However, validation of such tools is challenging and comprehensive invasive da ...

2009

The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar

Yann Barrandon, Lukas Kappenberger, Hans-Anton Lehr

Objective: The MRL mouse strain shows extraordinary wound healing capacities. Some years ago, Leferovich et al. (Proc Natl Acad Sci U. S. A. 2001;98:9830-35) have reported the absence of scar formation after cryogenically-induced right ventricular myocardi ...

Elsevier2008

Analysis of electrocardiograms during atrial fibrillation

Jean-Marc Vesin, Vincent Jacquemet, Lukas Kappenberger

The research discussed in this article is motivated by the search for an optimal classification of the different types of atrial fibrillation (AF) on the basis of recorded atrial signals. This would facilitate the selection of an optimal therapy. This arti ...

2006

Optimizing Local Capture of Atrial Fibrillation by Rapid Pacing: Study of the Influence of Tissue Dynamics

Jean-Marc Vesin, Vincent Jacquemet, Lukas Kappenberger, Laurent Renaud Uldry

While successful termination by pacing of organized atrial tachycardias has been observed in patients, rapid pacing of AF can induce a local capture of the atrial tissue but in general no termination. The purpose of this study was to perform a systematic e ...

Springer Verlag2010

Optimization of antitachycardia pacing protocols applied to atrial fibrillation: insights from a biophysical model

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry

We present a model-based systematic study of antitachycardia pacing protocols applied to atrial fibrillation, focusing on the ability to achieve and maintain capture during pacing, as a function of both pacing site and period. We observed that pacing sites ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2009

Study of the effect of rapid pacing of atrial fibrillation on the non-paced atrium

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry

Purpose: Experimental studies showed that local capture of atrial fibrillation (AF) by rapid pacing was possible in humans. However, contradictory observations were reported on its effect at distant atrial sites. The present model-based study investigated ...

2011

The effect of pacing site and frequency on capture of atrial fibrillation observed in a biophysical model

Jean-Marc Vesin, Lukas Kappenberger, Laurent Renaud Uldry

2009

Spontaneous termination of atrial fibrillation: study of the effect of atrial geometry in a biophysical model

Jean-Marc Vesin, Vincent Jacquemet, Lukas Kappenberger, Laurent Renaud Uldry

We studied the mechanisms of spontaneous termination of atrial fibrillation in a biophysical model of human atria, during the eight seconds preceding termination. The earliest detectable changes in the cycle length and the number of wavefronts occurred abo ...

Ieee Service Center, 445 Hoes Lane, Po Box 1331, Piscataway, Nj 08855-1331 Usa2009

Lukas Kappenberger

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Estimating the time scale and anatomical location of atrial fibrillation spontaneous termination in a biophysical model

Full Spectral Analysis of the Atrial Components in the ECG during Atrial Fibrillation

Novel complexity measurements in the ECG differentiate persistent from permanent atrial fibrillation

Harmonic frequency tracking algorithm for predicting the success of pharmacological cardioversion of atrial fibrillation

Measures of spatiotemporal organization differentiate persistent from long-standing atrial fibrillation

Susceptibility to Paroxysmal Atrial Fibrillation: A Study using Sinus Rhythm P Wave Parameters

Usefulness of P-Wave Duration and Morphologic Variability to Identify Patients Prone to Paroxysmal Atrial Fibrillation

Atrial septal pacing for the termination of atrial fibrillation: study in a biophysical model of human atria

The Role of Atrial Modeling in the Development of ECG Processing Tools

The MRL mouse repairs both cryogenic and ischemic myocardial infarcts with scar

Analysis of electrocardiograms during atrial fibrillation

Optimizing Local Capture of Atrial Fibrillation by Rapid Pacing: Study of the Influence of Tissue Dynamics

Optimization of antitachycardia pacing protocols applied to atrial fibrillation: insights from a biophysical model

Study of the effect of rapid pacing of atrial fibrillation on the non-paced atrium

The effect of pacing site and frequency on capture of atrial fibrillation observed in a biophysical model

Spontaneous termination of atrial fibrillation: study of the effect of atrial geometry in a biophysical model

Cancellation of Ventricular Activity in the ECG: Evaluation of novel and existing methods

Spectral analysis of the ECG identifies dominant rotors during atrial fibrillation

Wavelength and Vulnerability to Atrial Fibrillation: Insights from a Computer Model of Human Atria

The hidden organization of atrial fibrillation