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Sandor Kasas

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Related publications (77)

Amyloid Single Cell Cytotoxicity Assays by Nanomotion Detection

Giovanni Dietler, Sandor Kasas, Hilal Lashuel, Giovanni Longo, Francesco Simone Ruggeri, Anne-Laure Mahul Mellier

Cells are extremely complex systems able to modify actively their metabolism and behaviour in response to environmental conditions and stimuli, such as pathogenic agents or drugs. The comprehension of these responses is central to understand the molecular ...

Springer Nature2017

A Robust Actin Filaments Image Analysis Framework

Giovanni Dietler, Sandor Kasas

The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...

Public Library of Science2016

Localization of adhesins on the surface of a pathogenic bacterial envelope through atomic force microscopy

Sandor Kasas, Giovanni Longo, Petar Stupar

Bacterial adhesion is the first and a significant step in establishing infection. This adhesion normally occurs in the presence of flow of fluids. Therefore, bacterial adhesins must be able to provide high strength interactions with their target surface in ...

Royal Society of Chemistry2015

Detect the life through atomic force microscopy

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Petar Stupar

Edp Sciences S A2015

Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival

Jens Nielsen, Sandor Kasas, Livan Bladimir Alonso Sarduy

We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and ...

American Society for Microbiology2015

Detecting nanoscale vibrations as signature of life

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Francesco Simone Ruggeri, Petar Stupar

The existence of life in extreme conditions, in particular in extraterrestrial environments, is certainly one of the most intriguing scientific questions of our time. In this report, we demonstrate the use of an innovative nanoscale motion sensor in life-s ...

National Academy of Sciences2015

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure

Sandor Kasas

Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether IT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, ...

Elsevier2014

Effects of antibacterial agents and drugs monitored by atomic force microscopy

Sandor Kasas, Giovanni Longo

Originally invented for topographic imaging, atomic force microscopy (AFM) has evolved into a multifunctional biological toolkit, enabling to measure structural and functional details of cells and molecules. Its versatility and the large scope of informati ...

Wiley-Blackwell2014

Real-Time Monitoring of Protein Conformational Changes Using a Nano-Mechanical Sensor

Giovanni Dietler, Paolo De Los Rios, Dusan Vobornik, Sandor Kasas, Livan Bladimir Alonso Sarduy, Fabrizio Benedetti, Giovanni Longo

Proteins can switch between different conformations in response to stimuli, such as pH or temperature variations, or to the binding of ligands. Such plasticity and its kinetics can have a crucial functional role, and their characterization has taken center ...

Public Library of Science2014

A universal fluid cell for the imaging of biological specimens in the atomic force microscope

Charles Roduit, Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo, Bhaskar Saha

Recently, atomic force microscope (AFM) manufacturers have begun producing instruments specifically designed to image biological specimens. In most instances, they are integrated with an inverted optical microscope, which permits concurrent optical and AFM ...

Wiley-Blackwell2013

Rapid detection of bacterial resistance to antibiotics using AFM cantilevers as nanomechanical sensors

Giovanni Dietler, Sandor Kasas, Justin Terence Notz Pekkanen, Livan Bladimir Alonso Sarduy, Giovanni Longo, Laura Rio Marques

The widespread misuse of drugs has increased the number of multiresistant bacteria1, and this means that tools that can rapidly detect and characterize bacterial response to antibiotics are much needed in the management of infections. Various techniques, s ...

Nature Publishing Group2013

Nanoscale motion detector

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo

Motion detector comprising a flexible support (1,5) adapted to hold at least one object (6-9), a sensor (4) for measuring the displacement of said support (1) and processing means for differentiating the fluctuations of said support (1) from those induced ...

2013

Time-Lapse AFM Imaging of DNA Conformational Changes Induced by Daunorubicin

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Giovanni Longo

Cancer is a major health issue that absorbs the attention of a large part of the biomedical research. Intercalating agents bind to DNA molecules and can inhibit their synthesis and transcription; thus, they are increasingly used as drugs to fight cancer. I ...

American Chemical Society2013

Combination of fluorescence microscopy and nanomotion detection to characterize bacteria

Giovanni Dietler, Sandor Kasas, Justin Terence Notz Pekkanen, Giovanni Longo

Antibiotic-resistant pathogens are a major health concern in everyday clinical practice. Because their detection by conventional microbial techniques requires minimally 24h, some of us have recently introduced a nanomechanical sensor, which can reveal moti ...

Wiley-Blackwell2013

Stiffness tomography exploration of living and fixed macrophages

Charles Roduit, Giovanni Dietler, Sandor Kasas, Andrea Volterra, Giovanni Longo, Bhaskar Saha

Stiffness tomography is a new atomic force microscopy imaging technique that allows highlighting structures located underneath the surface of the sample. In this imaging mode, such structures are identified by investigating their mechanical properties. We ...

Wiley-Blackwell2012

Force volume and stiffness tomography investigation on the dynamics of stiff material under bacterial membranes

Charles Roduit, Giovanni Dietler, Sandor Kasas, Giovanni Longo, Laura Rio Marques

The determination of the characteristics of micro-organisms in clinical specimens is essential for the rapid diagnosis and treatment of infections. A thorough investigation of the nanoscale properties of bacteria can prove to be a fundamental tool. Indeed, ...

Wiley-Blackwell2012

Atomic Force Microscopy Stiffness Tomography on Living Arabidopsis thaliana Cells Reveals the Mechanical Properties of Surface and Deep Cell-Wall Layers during Growth

Charles Roduit, Giovanni Dietler, Sandor Kasas, Christian Fankhauser

Cell-wall mechanical properties play a key role in the growth and the protection of plants. However, little is known about genuine wall mechanical properties and their growth-related dynamics at subcellular resolution and in living cells. Here, we used ato ...

Elsevier2012

Differential peptide binding to CD40 evokes counteractive responses

Charles Roduit, Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Bhaskar Saha

The antigen-presenting cell-expressed CD40 is implied in the regulation of counteractive immune responses such as induction of pro-inflammatory and anti-inflammatory cytokines interleukin (IL)-12 and IL-10, respectively. The mechanism of this duality in CD ...

Elsevier2012

Differential peptide binding to CD40 evokes counteractive responses (vol 73, pg 465, 2012)

Charles Roduit, Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Bhaskar Saha

Elsevier2012

Determination of the size of quantum dots by fluorescence spectroscopy

Sandor Kasas

There has been a lack of quick, simple and reliable methods for determination of nanoparticle size. An investigation of the size of hydrophobic (CdSe) and hydrophilic (CdSe/ZnS) quantum dots was performed by using the maximum position of the corresponding ...

2011

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