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Sandor Kasas

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Related publications (75)

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Candida albicans Adhesion Measured by Optical Nanomotion Detection

Sandor Kasas

Cellular adhesion plays an important role in numerous fundamental physiological and pathological processes. Its measurement is relatively complex, requires sophisticated equipment, and, in most cases, cannot be carried out without breaking the links betwee ...

MDPI2023

Mitochondrial nanomotion measured by optical microscopy

Sandor Kasas, María Inés Villalba

Nanometric scale size oscillations seem to be a fundamental feature of all living organisms on Earth. Their detection usually requires complex and very sensitive devices. However, some recent studies demonstrated that very simple optical microscopes and de ...

Frontiers Media SA2023

3D printed fiber-optic nanomechanical bioprobe

Sandor Kasas, Jiangtao Zhou

Ultrasensitive nanomechanical instruments, e.g. atomic force microscopy (AFM), can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological processes. However, these instruments are limited because ...

IOP Publishing Ltd2023

Stiffness Tomography by Atomic Force Microscopy

Giovanni Dietler, Sandor Kasas, Serguei Sekatski, Charles Roduit

The atomic force microscope is a convenient tool to probe living samples at the nanometric scale. Among its numerous capabilities, the instrument can be operated as a namo-indenter to gather information about the mechanical properties of the sample. In thi ...

2009

DNA-protein interactions explored by atomic force microscopy

Giovanni Dietler, Sandor Kasas

DNA-protein interactions play an important role in all living organisms on Earth. The advent of atomic force microscopy permitted for the first time to follow and to characterize interaction forces between these two molecular species. After a short descrip ...

Elsevier2018

Methods and systems for particle characterisation

Sandor Kasas, Anton Malovichko

A method and system for deriving particle characteristics is described. The method comprises imaging the movement of at least one free-floating particle in a liquid environment at at least one moment in time, determining for at least one moment in time a m ...

2020

Optical Nanomotion Detection to Rapidly Discriminate between Fungicidal and Fungistatic Effects of Antifungals on Single-Cell Candida albicans

Sandor Kasas, María Inés Villalba

Candida albicans is an emerging pathogen that poses a significant challenge due to its multidrug-resistant nature. There are two types of antifungal agents, fungicidal and fungistatic, with distinct mechanisms of action against fungal pathogens. Fungicidal ...

MDPI AG2024

Yeast Nanometric Scale Oscillations Highlights Fibronectin Induced Changes in C. albicans

Giovanni Dietler, Sandor Kasas, Leonardo Venturelli, Anne-Céline Verenna Kohler

Yeast resistance to antifungal drugs is a major public health issue. Fungal adhesion onto the host mucosal surface is still a partially unknown phenomenon that is modulated by several actors among which fibronectin plays an important role. Targeting the ye ...

2020

A Robust Actin Filaments Image Analysis Framework

Giovanni Dietler, Sandor Kasas

The cytoskeleton is a highly dynamical protein network that plays a central role in numerous cellular physiological processes, and is traditionally divided into three components according to its chemical composition, i.e. actin, tubulin and intermediate fi ...

Public Library of Science2016

Localization of adhesins on the surface of a pathogenic bacterial envelope through atomic force microscopy

Sandor Kasas, Giovanni Longo, Petar Stupar

Bacterial adhesion is the first and a significant step in establishing infection. This adhesion normally occurs in the presence of flow of fluids. Therefore, bacterial adhesins must be able to provide high strength interactions with their target surface in ...

Royal Society of Chemistry2015

Temperature-Dependent Elasticity of Microtubules

László Forró, Andras Kis, Andrzej Kulik, Sandor Kasas

Central to the biological function of microtubules. is their ability to modify their length which occurs by addition and removal of subunits at the ends of the polymer, both in vivo and in vitro. This dynamic behavior is strongly influenced by temperature. ...

American Chemical Society2008

Microcontroller-driven fluid-injection system for atomic force microscopy

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy

We present a programmable microcontroller-driven injection system for the exchange of imaging medium during atomic force microscopy. Using this low-noise system, high-resolution imaging can be performed during this process of injection without disturbance. ...

American Institute of Physics2010

Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure

Sandor Kasas

Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However, whether IT per se or the overall sarcolemma is altered during HF process is still unknown. In this study, ...

Elsevier2014

A perspective view on the nanomotion detection of living organisms and its features

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Petar Stupar, María Inés Villalba, Leonardo Venturelli, Anne-Céline Verenna Kohler

The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tool ...

WILEY2020

Probing nanomechanical properties from biomolecules to living cells

Giovanni Dietler, Sandor Kasas

Atomic force microscopy is being increasingly used to explore the physical properties of biological structures. This technique involves the application of a force to the sample and a monitoring of the ensuing deformation process. The available experimental ...

Springer-Verlag2008

Human topoisomerase II-DNA interaction study by using atomic force microscopy

Giovanni Dietler, Sandor Kasas, Livan Bladimir Alonso Sarduy, Charles Roduit

AFM; DNA topology; Human topoisomerase II; Binding geometry; Time-lapse imaging; Protein–DNA interaction ...

Elsevier2011

Cellular toxicity of carbon-based nanomaterials

László Forró, Arnaud Magrez, Sandor Kasas, Jin Won Seo

The cellular toxicity of carbon-based nanomaterials was studied as a function of their aspect ratio and surface chemistry. These structures were multiwalled carbon nanotubes, carbon nanofibers, and carbon nanoparticles. Their toxicity was tested in vitro o ...

2006

Effect of antibiotics on mechanical properties of Bordetella pertussis examined by atomic force microscopy

Giovanni Dietler, Sandor Kasas, María Inés Villalba, Leonardo Venturelli

In recent years, the coevolution of microorganisms with current antibiotics has increased the mechanisms of bacterial resistance, generating a major health problem worldwide. Bordetella pertussis is a bacterium that causes whooping cough and is capable of ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Determination of the size of quantum dots by fluorescence spectroscopy

Sandor Kasas

There has been a lack of quick, simple and reliable methods for determination of nanoparticle size. An investigation of the size of hydrophobic (CdSe) and hydrophilic (CdSe/ZnS) quantum dots was performed by using the maximum position of the corresponding ...

2011

Stiffness tomography by atomic force microscopy

Sandor Kasas, Charles Roduit

A method of analyzing a sample with a probe based measurement instrument using stiffness tomography. Stiffness or elastic modulus data obtained through contact measurement with the sample as a function of depth is used in the detection of features, particu ...

2007