Vassily HatzimanikatisDr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Vassily received a PhD and an MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology in Zurich (ETHZ), Switzerland. Prior to joining EPFL, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, and he has been assistant professor at Northwestern University, at Illinois, USA.
Vassilys research interests are in the areas of computational systems biology, biotechnology, and complexity. He is associate editor of the journals Biotechnology & Bioengineering, Metabolic Engineering and Integrative Biology, and he serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering, Journal of Chemical Technology and Biotechnology, and Industrial Biotechnology. He has written over 70 technical publications and he is co-inventor in three patents and patent applications.
Vassily is a fellow of the American Institute for Medical and Biological Engineering (2010), he was a DuPont Young Professor (2001-2004), and he has also received the Jay Bailey Young Investigator Award in Metabolic Engineering (2000), and the ACS Elmar Gaden Award (2011).
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Coralie BussoExpériences professionnelles Apprentie Laborantine 2001–2004 CMU Dpt. de physiologie cellulaire et métabolisme
RechercheCentrosomes promote timely mitotic entry in C. ele Dev Cell. 2007 Apr;12(4):531-41.Centrosomes promote timely mitotic entry in C. elegans embryos.Hachet V, Canard C, Gönczy P.SourceSwiss Institute for Experimental Cancer Research (ISREC), and School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1066 Lausanne, Switzerland.AbstractSeveral mitotic regulators, including
Rizlan Bernier-LatmaniHIGHER EDUCATION
Summer course: Advances in Genome Technology and Bioinformatics Course at the Marine Biology Laboratory in Woods Hole, MA. October 2005.
Ph.D. 2001 Civil and Environmental Engineering, Stanford University, CA
(Advisor, Jim Leckie, Biodegradation of uranyl (UO22 )-complexed citrate and implications for uranyl mobility in the subsurface)
M.S. 1995 Civil and Environmental Engineering, Stanford University, CA
B.S. 1993 Natural Resources with Honors, Cornell University, Ithaca, NY
PROFESSIONAL EMPLOYMENT
2013-present Associate professor with tenure, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2005-2013 Assistant professor tenure track, School of Architecture, Civil and Environmental Engineering, Swiss Federal Institute of Technology, Lausanne
2001-2005 Post-Graduate Researcher, Scripps Institution of Oceanography, La Jolla, CA (PI: Brad Tebo)
1995-2001 Graduate Research Assistant, Stanford University (Advisor: Jim Leckie)
RESEARCH INTERESTS
Gemicrobiology, metal-bacteria interactions, biological reduction and oxidation of metals, biological nanoparticle formation; Characterization of microbial communities in terrestrial environments; Using genomic, microscopic and spectroscopic tools to understand metal transformations by microorganisms.
ACADEMIC HONORS
Rotary Foundation University Professor grant, 2004.
Swiss National Science Foundation Post-doctoral Fellowship, 2001.
Leon B. Reynolds Memorial Scholarship in the School of Engineering at Stanford University, 1995-96.
Graduated with Honors from Cornell University, 1993.
BIBLIOMETRY
http://www.researcherid.com/rid/E-4398-2011
ResearcherID: E-4398-2011 Herbert SheaExpertise
soft robotics, wearable haptics, electrostatic actuators, EHD
Mission
My lab develops flexible polymer-based actuators for a wide range of applications including haptics and soft robotics. More info at https://www.epfl.ch/labs/lmts/
Links from EPFL-LMTS Lab webpage People Research ActivitiesPublications TeachingPublications and Conference papers Link to my lab Education PhD | Physics 1997 – 1997 Harvard University MA | Physics 1993 – 1993 Harvard University Kristina SchoonjansExpertise
Bile acid signalingNutrient sensingIntermediary metabolismMetabolic disorders
Teaching & PhD PhD Students Adrien Faure Past EPFL PhD Students Pan Xu, Ece Yildiz, Nadia Bresciani, Yu Sun, Francesca Pontanari, Alejandro Alonso Calleja Past EPFL PhD Students as codirector Mitsunori Nomura, Pan Xu, Katyayanee Neopane, Lucie Camille Chanvillard, Jakob Josef Langer, Bilge Sen Elçi Courses General Biology BIOENG-110 The purpose of the course is to provide a general overview of the biolo
Andrea KrappTeaching & PhD Past EPFL PhD Students as codirector Claudia Melcarne Courses Practical - Karthaus Lab BIO-616 Students will learn 1) how organoids can be used in biomedical research 2) How to perform organoid culture 3) How to perform basic genetic manipulations
Chiara GabellaTeaching & PhD Courses Hands-on with Research Data Management in Chemistry ChE-601 PhD students in Chemistry will learn hands-on Research Data Management (RDM) skills transferable to their research practices. They willcontextualize their research into RDM best practices (day 1), discover appropriate tools (day 2) and work on a project (day 3) for the courseaccreditation
Priscilla TurelliPositions
2005-now: Research associate, Federal School of Life Sciences, Laboratory of Virology and Genetics, Lausanne, Switzerland
2001-2004: Research associate in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland
1997-2001: Post-doctoral research fellow in Pr D. Tronos laboratory, Department of Microbiology, Geneva School of Medicine, Switzerland
Honors and fellowships
2004: Bristol-Myers Squibb AIDS AWARD
1997-1999: Human Frontier Science Program fellowship
Education
June 1997:
PhD in cellular biology.
Final mark:jury congratulations.
Université de la Méditerranée, France.
June 1993:
Post-graduate diploma in cellular biology and microbiology.
INSERM U372, Marseille-Luminy, université de Provence, France.
June 1992:
Master in cellular biology Specialty: genetic.
Final mark: Best master student of this year.
Université de la Méditerranée, France.
June 1987:
Scientific baccalaureate, France.
Teaching experience
2009-now: phD thesis co-director, School of Life Sciences, Lausanne, Switzerland.
2002: Tutor in virology for medical students, 2nd year, Geneva School of Medicine, Switzerland.
1996-1997: Tutor in molecular biology and biochemistry for under-graduate students,
Université de la Méditerranée, Aix Marseille II, France.
Ute KochExpertise
SCIENTIFIC EXPERTISESCurrent Molecular Biology and Cloning, Developmental Biology, Cellular and Molecular Immunology, Lymphocyte Maturation and Lineage Commitment, Thymic Selection, Hematopoietic Stem Cell Biology, Bone Marrow Transplantation, Graft-versus-Host Disease, Skin Transplantation, T Lymphocyte Subset Induction (Th1 - Th2, Cytokine Regulation), Extensive Knowledge in Flow CytometryIT SKILLSMicrosoft-Office: Word, Excel, PowerPoint.File Maker Pro: Database design and management.Flow cytom
