Publications by Marc Hafner | EPFL Graph Search

Related publications (13)

Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus

In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus constitutes the central circadian pacemaker. The SCN receives light signals from the retina and controls peripheral circadian clocks (located in the cortex, the pineal gland, the liver, the ...

Public Library of Science2012

Explaining the length threshold of polyglutamine aggregation

Paolo De Los Rios, Marc Hafner

The existence of a length threshold, of about 35 residues, above which polyglutamine repeats can give rise to aggregation and to pathologies, is one of the hallmarks of polyglutamine neurodegenerative diseases such as Huntington's disease. The reason why s ...

2012

Evolution of feedback loops in oscillatory systems

Marc Hafner

Feedback loops are major components of biochemical system. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses that address the question how such multiple feedback loops evolved. Based on publ ...

2009

Efficient characterization of high-dimensional parameter spaces for systems biology

Marc Hafner

Background: A biological system's robustness to mutations and its evolution are influenced by the structure of its viable space, the region of its space of biochemical parameters where it can exert its function. In systems with a large number of biochemica ...

2011

Positive feedbacks contribute to the robustness of the cell cycle with respect to molecular noise

Marc Hafner

Most cellular oscillators rely on interlocked positive and negative regulatory feedback loops. While a negative circuit is necessary and sufficient to have limit-cycle oscillations, the role of positive feedbacks is not clear. Here we investigate the possi ...

Springer Verlag2010

New microwave sensing system for blade tip clearance measurement in gas turbines

Anja Skrivervik, Marc Hafner, Maddalena Violetti

Real-time clearance control in turbine engines allows improving their efficiency and safety, by enabling prognostics and optimized condition-based maintenance in the turbine hot section. This paper presents a novel 24 GHz microwave sensing system for real- ...

Ieee2012

'Glocal' Robustness Analysis and Model Discrimination for Circadian Oscillators

Martin Hasler, Marc Hafner

To characterize the behavior and robustness of cellular circuits with many unknown parameters is a major challenge for systems biology. Its difficulty rises exponentially with the number of circuit components. We here propose a novel analysis method to mee ...

2009

Robustness and evolution in oscillatory systems with feedback loops

Marc Hafner

Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on publishe ...

2009

Evolution of Feedback Loops in Oscillatory Systems

Marc Hafner

Feedback loops are major components of biochemical systems. Many systems show multiple such (positive or negative) feedback loops. Nevertheless, very few quantitative analyses address the question how such multiple feedback loops evolved. Based on publishe ...

2009

Quantitative Analysis of Robustness in Systems Biology : Combining Global and Local Approaches

Marc Hafner

To characterize the behavior and robustness of cellular circuits is a major challenge for Systems Biology. Many of the published methods that address this question quantify the local robustness of the models. In this thesis, I tried to underpin the inappro ...

EPFL2010

Marc Hafner

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Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus

Explaining the length threshold of polyglutamine aggregation

Evolution of feedback loops in oscillatory systems

Efficient characterization of high-dimensional parameter spaces for systems biology

Positive feedbacks contribute to the robustness of the cell cycle with respect to molecular noise

New microwave sensing system for blade tip clearance measurement in gas turbines

'Glocal' Robustness Analysis and Model Discrimination for Circadian Oscillators

Robustness and evolution in oscillatory systems with feedback loops

Evolution of Feedback Loops in Oscillatory Systems

Quantitative Analysis of Robustness in Systems Biology : Combining Global and Local Approaches

Rule-based modeling for protein-protein interaction networks - the cyanobacterial circadian clock as a case study

Multiple feedback loops in circadian cycles: robustness and entrainment as selection criteria

Semi-quantitative stability analysis constrains saturation levels in metabolic networks