Stéphane JoostExpertise
Geographic Information Science and spatial statisticsMolecular ecology, Landscape genomics, Seascape genomicsSpatial epidemiology, Health geographics
Publications Publications- List of publications
Teaching & PhD PhD Students Marco André Vieira Ruas, Manon Laetitia Pribille, Martine Valérie Besse Past EPFL PhD Students Estelle Rochat, Solange Catherine Gaillard, Oliver Michele Selmoni, Anaïs Ladoy, Annie Sandrine Guillaume Past EPFL PhD Students as codirector Sylvie Stucki, Kevin Leempoel, Martí
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Serge VaudenaySerge Vaudenay entered at the Ecole Normale Supérieure in 1989 with a major in mathematics. He earned his agrégation (secondary teaching degree) in mathematics in 1992, then a PhD in Computer Science at the University of Paris 7 - Denis Diderot in 1995. He subsequently became a senior research fellow at the CNRS, prior to being granted his habilitation à diriger des recherches (a postdoctoral degree authorizing the recipient to supervise doctoral students). In 1999, he was appointed as a Professor at the EPFL, where he created the Security and Cryptography Laboratory.
François MaréchalPh D. in engineering Chemical process engineer
Researcher and lecturer in the field of computer aided process and energy systems engineering.
Lecturer in the mechanical engineering, electrical engineering and environmental sciences engineering in EPFL.
I'm responsible for the Minor in Energy of EPFL and I'm involved in 3 projects of the Competence Center in Energy and Mobility (2nd generation biofuel, Wood SOFC, and gas turbine development with CO2 mitigation) in which i'm contributing to the energy conversion system design and optimisation.
Short summary of my scientific carrer
After a graduation in chemical engineering from the University of Liège, I have obtained a Ph. D. from the University of Liège in the LASSC laboratory of Prof. Kalitventzeff (former president of the European working party on computer aided process engineering). This laboratory was one of the pioneering laboratory in the field of Computer Aided Process Engineering.
In the group of Professor Kalitventzeff, I have worked on the development and the applications of data reconciliation, process modelling and optimisation techniques in the chemical process industry, my experience ranges from nuclear power stations to chemical plants. In the LASSC, I have been responsible from the developments in the field of rational use of energy in the industry. My first research topic has been the methodological development of process integration techniques, combining the use of pinch based methods and of mathematical programming: e.g. for the design of multiperiod heat exchanger networks or Mixed integer non linear programming techniques for the optimal management of utility systems. Fronted with applications in the industry, my work then mainly concentrated on the optimal integration of utility systems considering not only the energy requirements but the cost of the energy requirements and the energy conversion systems. I developed methods for analysing and integrating the utility system, the steam networks, combustion (including waste fuel), gas turbines or other advanced energy conversion systems (cogeneration, refrigeration and heat). The techniques applied uses operation research tools like mixed integer linear programming and exergy analysis. In order to evaluate the results of the utility integration, a new graphical method for representing the integration of the utility systems has been developed. By the use of MILP techniques, the method developed for the utility integration has been extended to handled site scale problems, to incorporate environmental constraints and reduce the water usage. This method (the Effect Modelling and Optimisation method) has been successfully applied to the chemical plants industry, the pulp and paper industry and the power plant. Instead of focusing on academic problems, I mainly developed my research based on industrial applications that lead to valuable and applicable patented results. Recently the methods developed have been extended to realise the thermoeconomic optimisation of integrated systems like fuel cells. My present R&D work concerns the application of multi-objective optimisation strategies in the design of processes and integrated energy conversion systems.
Since 2001, Im working in the Industrial Energy Systems Laboratory (LENI) of Ecole Polytechnique fédérale de Lausanne (EPFL) where Im leading the R&D activities in the field of Computer Aided Analysis and Design of Industrial Energy Systems with a major focus on sustainable energy conversion system development using thermo-economic optimisation methodologies. A part from the application and the development of process integration techniques, that remains my major field of expertise, the applications concern :
Rational use of water and energy in Industrial processes and industrial production sites : projects with NESTLE, EDF, VEOLIA and Borregaard (pulp and paper).Energy conversion and process design : biofuels from waste biomass (with GASNAT, EGO and PSI), water dessalination and waste water treatment plant (VEOLIA), power plant design (ALSTOM), Energy conversion from geothermal sources (BFE). Integrated energy systems in urban areas : together with SCANE and SIG (GE) and IEA annexe 42 for micro-cogeneration systems.
I as well contributed to the definition of the 2000 Watt society and to studies concerning the emergence of green technologies on the market in the frame of the Alliance for Global Sustainability.
Babak FalsafiBabak is a Professor in the School of Computer and Communication Sciences and the founding director of the EcoCloud, an industrial/academic consortium at EPFL investigating scalable data-centric technologies. He has made numerous contributions to computer system design and evaluation including a scalable multiprocessor architecture which was prototyped by Sun Microsystems (now Oracle), snoop filters and memory streaming technologies that are incorporated into IBM BlueGene/P and Q and ARM cores, and computer system performance evaluation methodologies that have been in use by AMD, HP and Google PerKit . He has shown that hardware memory consistency models are neither necessary (in the 90's) nor sufficient (a decade later) to achieve high performance in multiprocessor systems. These results eventually led to fence speculation in modern microprocessors. His latest work on workload-optimized server processors laid the foundation for the first generation of Cavium ARM server CPUs, ThunderX. He is a recipient of an NSF CAREER award, IBM Faculty Partnership Awards, and an Alfred P. Sloan Research Fellowship. He is a fellow of IEEE and ACM.
Samy BengioExpertise
Large Language ModelsReasoningStatistical machine learningSpeech processingPerson authenticationMultimodal processingSequence processingArtificial neural networks, support vector machinesHidden markov models, gaussian mixture modelsetc
Expertise
Large Language ModelsReasoningStatistical machine learningSpeech processingPerson authenticationMultimodal processingSequence processingArtificial neural networks, support vector machinesHidden markov models, gaussian mixture modelsetc
Mission
Samy Bengio
Jean-François MolinariProfessor J.F. Molinari is the director of the Computational Solid Mechanics Laboratory (http://lsms.epfl.ch) at EPFL, Switzerland. He holds an appointment in the Civil Engineering institute, which he directed from 2013 to 2017, and a joint appointment in the Materials Science institute. He started his tenure at EPFL in 2007, and was promoted to Full Professor in 2012. He is currently an elected member of the Research Council of the Swiss National Science Foundation in Division 2 (Mathematics, Natural and Engineering Sciences), and co editor in chief of the journal Mechanics of Materials. J.F. Molinari graduated from Caltech, USA, in 2001, with a M.S. and Ph.D. in Aeronautics. He held professorships in several countries besides Switzerland, including the United States with a position in Mechanical Engineering at the Johns Hopkins University (2000-2006), and France at Ecole Normale Supérieure Cachan in Mechanics (2005-2007), as well as a Teaching Associate position at the Ecole Polytechnique de Paris (2006-2009). The work conducted by Prof. Molinari and his collaborators takes place at the frontier between traditional disciplines and covers several length scales from atomistic to macroscopic scales. Over the years, Professor Molinari and his group have been developing novel multiscale approaches for a seamless coupling across scales. The activities of the laboratory span the domains of damage mechanics of materials and structures, nano- and microstructural mechanical properties, and tribology. Olivier MartinOlivier J.F. Martin received the M.Sc. and Ph.D. degrees in physics in 1989 and 1994, respectively, from the Swiss Federal Institute of Technology, Lausanne (EPFL), Switzerland. In 1989, he joined IBM Zurich Research Laboratory, where he investigated thermal and optical properties of semiconductor laser diodes. Between 1994 and 1997 he was a research staff member at the Swiss Federal Institute of Technology, Zurich (ETHZ). In 1997 he received a Lecturer fellowship from the Swiss National Science Foundation (SNSF). During the period 1996-1999, he spent a year and a half in the U.S.A., as invited scientist at the University of California in San Diego (UCSD). In 2001 he received a Professorship grant from the SNSF and became Professor of Nano-Optics at the ETHZ. In 2003, he was appointed Professor of Nanophotonics and Optical Signal Processing at the Swiss Federal Institute of Technology, Lausanne (EPFL), where he is currently head of the Nanophotonics and Metrology Laboratory and Director of the Microengineering Section.
Aleksandra RadenovicFrom April 2021 Full Professor 2015 -2021 Associate Professor2008-2015 Tenure-Track Assistant Professor2004-2007 Postdoc at the University of California, Berkeley in the group of Prof.Liphardt2003 PhD student of Prof. Dietler in Laboratory of Physics of Living Matter, University of Lausanne 1999 Diploma thesis on the subject of the Raman spectroscopy of beta carotene1994-1999 Physics department at the University of Zagreb1994 baccalaureate, Classical gymnasium
Emmanuel AbbéTeaching & PhD PhD Students Denys Pushkin, Ortal Yona Senouf, Vladyslav Shashkov Past EPFL PhD Students Elisabetta Cornacchia, Aryo Lotfi Courses Reasoning in artificial intelligence MATH-700 Large language models have raised the potential of artificial intelligence in various applications, including science and mathematics, but their reasoning capabilities remain under investigations. This class focuses on defining, measuring and improving the reasoning capabilities of such AI models.
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Mathew Magimai DossTeaching & PhD PhD Students Karl El Hajal, Tilak Purohit Past EPFL PhD Students as codirector Ramya Rasipuram, Marzieh Razavi, Hannah Muckenhirn, Sandrine Tornay, Subrahmanya Pavankumar Dubagunta, Enno Hermann, Julian David Fritsch, Neha Tarigopula, Mostaani Zohreh, Eklavya Sarkar Courses Automatic speech processing EE-554 The goal of this course is to provide the students with the main formalisms, models and algorithms required for the implementation of advanced speech processing applicat
