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Alfio Quarteroni

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Related publications (251)

Hemodynamics of the heart's left atrium based on a Variational Multiscale-LES numerical method

In this paper, we investigate the haemodynamics of a left atrium (LA) by proposing a computational model suitable to provide physically meaningful fluid dynamics indications and detailed blood flow characterization. In particular, we consider the incompres ...

ELSEVIER2021

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Alfio Quarteroni

Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used strategy to include ...

ELSEVIER SCIENCE SA2021

Three-dimensional physics-based earthquake ground motion simulations for seismic risk assessment in densely populated urban areas

Alfio Quarteroni

In this paper we describe a mathematical and numerical approach that combines physics-based simulated ground motion caused by earthquakes with fragility functions to model the structural damages induced to buildings. To simulate earthquake ground motion we ...

2021

POD-Enhanced Deep Learning-Based Reduced Order Models for the Real-Time Simulation of Cardiac Electrophysiology in the Left Atrium

Alfio Quarteroni, Andrea Manzoni

The numerical simulation of multiple scenarios easily becomes computationally prohibitive for cardiac electrophysiology (EP) problems if relying on usual high-fidelity, full order models (FOMs). Likewise, the use of traditional reduced order models (ROMs) ...

FRONTIERS MEDIA SA2021

Accelerating the convergence to a limit cycle in 3D cardiac electromechanical simulations through a data-driven 0D emulator

Alfio Quarteroni

The results of numerical simulations of cardiac electromechanics are typically characterized by a long transient before reaching a periodic solution known as limit cycle. This yields a serious computational overhead, as the only clinically relevant output ...

PERGAMON-ELSEVIER SCIENCE LTD2021

Electro-Mechanical Coupling in Human Atrial Cardiomyocytes: Model Development and Analysis of Inotropic Interventions

Alfio Quarteroni

Human-based computational models are a powerful tool that complements the experimental approaches and can improve our understanding of individual components of the heart by integrating them into one system. This paper aims to couple and calibrate a human a ...

IEEE2021

Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study

Alfio Quarteroni

Emerging studies address how COVID-19 infection can impact the human cardiovascular system. This relates particularly to the development of myocardial injury, acute coronary syndrome, myocarditis, arrhythmia, and heart failure. Prospective treatment approa ...

2021

Mathematical and numerical models for the cardiac electromechanical function

Alfio Quarteroni, Francesco Regazzoni

This paper deals with the mathematical model that describes the function of the human heart. More specifically, it addresses the equations that express the electromechanical process, that is the mechanical deformation (contraction and relaxation) of the he ...

EUROPEAN MATHEMATICAL SOC-EMS2021

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Alfio Quarteroni, Andrea Manzoni

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...

FRONTIERS MEDIA SA2021

Multipatch Isogeometric Analysis for electrophysiology: Simulation in a human heart

Alfio Quarteroni

In the framework of cardiac electrophysiology for the human heart, we apply multipatch NURBS-based Isogeometric Analysis for the space discretization of the Monodomain model. Isogeometric Analysis (IGA) is a technique for the solution of Partial Differenti ...

ELSEVIER SCIENCE SA2021

A mathematical dashboard for the analysis of Italian COVID-19 epidemic data

Alfio Quarteroni, Nicola Parolini, Luca Dede'

An analysis of the COVID-19 epidemic is proposed on the basis of the epiMOX dashboard (publicly accessible at ) that deals with data of the epidemic trends and outbreaks in Italy from late February 2020. Our analysis provides an immediate appreciation of t ...

Wiley2021

Numerical Analysis - A physics-informed multi-fidelity approach for the estimation of differential equations parameters in low-data or large-noise regimes

Alfio Quarteroni

In this paper, we propose a multi-fidelity approach for parameter estimation problems based on Physics-Informed Neural Networks (PINNs). The proposed methods apply to models expressed by linear or nonlinear differential equations, whose parameters need to ...

EUROPEAN MATHEMATICAL SOC-EMS2021

Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction

Alfio Quarteroni, Luca Dede', Francesco Regazzoni

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mech ...

SPRINGER SINGAPORE PTE LTD2021

Morphomechanical Model Of The Torsional C-Looping In The Embryonic Heart

Alfio Quarteroni

Before septation processes shape its four chambers, the embryonic heart is a straight tube that spontaneously bends and twists breaking the left-right symmetry. In particular, the heart tube is subjected to a cell remodeling inducing ventral bending and de ...

SIAM PUBLICATIONS2021

A computational model applied to myocardial perfusion in the human heart: From large coronaries to microvasculature

Alfio Quarteroni

In this paper we present a mathematical and numerical model for human cardiac perfusion which accounts for the different length scales of the vessels in the coronary tree. Epicardial vessels are represented with fully three-dimensional (3D) fluid-dynamics, ...

2021

SUIHTER: a new mathematical model for COVID-19. Application to the analysis of the second epidemic outbreak in Italy

Alfio Quarteroni

The COVID-19 epidemic is the latest in a long list of pandemics that have affected humankind in the last century. In this paper, we propose a novel mathematical epidemiological model named SUIHTER from the names of the seven compartments that it comprises: ...

ROYAL SOC2021

An oscillation-free fully staggered algorithm for velocity-dependent active models of cardiac mechanics

Alfio Quarteroni

In this paper we address an unresolved problem in the numerical modeling of cardiac electromechanics, that is the onset of numerical oscillations due to the dependence of force generation models on the fibers shortening velocity. A way to avoid numerical o ...

ELSEVIER SCIENCE SA2021

Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

Alfio Quarteroni

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model reproduces the activity both in sinus rhythm (SR) and in ventricular tachycard ...

PERGAMON-ELSEVIER SCIENCE LTD2021

A Proof of Concept for Computational Fluid Dynamic Analysis of the Left Atrium in Atrial Fibrillation on a Patient-Specific Basis

Alfio Quarteroni, Davide Forti, Filippo Menghini

Atrial fibrillation (AF) is associated with a fivefold increase in the risk of cerebrovascular events, being responsible of 15-18% of all strokes. The morphological and functional remodeling of the left atrium (LA) caused by AF favors blood stasis and, con ...

ASME2020

A mathematical model of the human heart

Alfio Quarteroni

In this paper, we present a mathematical model able to simulate the cardiac function. We first describe the basic physical principles behind the mathematical equations, then we illustrate a few examples of application to problems of clinical relevance. ...

PENSIERO SCIENTIFICO EDITOR2020

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