Didier TronoAfter obtaining an M.D. from the University of Geneva and completing a clinical training in pathology, internal medicine and infectious diseases in Geneva and at Massachusetts General Hospital in Boston, Didier Trono embarked in a scientific career at the Whitehead Institute for Biomedical Research of MIT. In 1990, he joined the faculty of the Salk Institute for Biological Studies to launch a center for AIDS research. He moved back to Europe seven years later, before taking the reins of the newly created EPFL School of Life Sciences, which he directed from 2004 to 2012. He is now actively engaged in the efforts of Switzerland to integrate new technologies in the fields of precision medicine and personalized health.
Simone DeparisExpertise
Simone Deparis is a professor at EPFL specializing in applied mathematics, numerical analysis, and the didactics of university-level mathematics. His research spans computational modeling for biomedical applications and innovations in mathematics education, with a focus on equity, self-efficacy, and assessment reform in large STEM cohorts.
Mission
Our group conducts research at the intersection of applied mathematics and learning sciences. In applied mathematics, we focus on modeling and simulatio
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Auke IjspeertAuke Ijspeert is a full professor at the EPFL, and head of the Biorobotics Laboratory (BioRob). He has a B.Sc./M.Sc. in physics from the EPFL (1995), and a PhD in artificial intelligence from the University of Edinburgh (1999). He carried out postdocs at IDSIA and EPFL, and at the University of Southern California (USC). He then became a research assistant professor at USC, and an external collaborator at ATR (Advanced Telecommunications Research institute) in Japan. In 2002, he came back to the EPFL as an SNF assistant professor. He was promoted to associate professor in October 2009 and to full professor in April 2016. His primary affiliation is with the Institute of Bioengineering, and secondary affiliation with the Institute of Mechanical Engineering. His research interests are at the intersection between robotics, computational neuroscience, nonlinear dynamical systems, and machine learning. He is interested in using numerical simulations and robots to get a better understanding of sensorimotor coordination in animals, and in using inspiration from biology to design novel types of robots and adaptive controllers. (see for instance Ijspeert et al Science 2007, Ijspeert Science 2014, and Nyakatura et al Nature 2019). He is also investigating how to assist people with limited mobility using exoskeletons and assistive furniture. He is regularly invited to give talks on these topics (e.g. TED talk given at TED Global Geneva, Dec 8 2015). With his colleagues, he has received paper awards at ICRA2002, CLAWAR2005, IEEE Humanoids 2007, IEEE ROMAN 2014, CLAWAR 2015, SAB2018, and CLAWAR 2019. He is an IEEE Fellow, member of the Board of Reviewing Editors of Science magazine, and associate editor for the IEEE Transactions on Medical Robotics and Bionics and for the International Journal of Humanoid Robotics. He has acted as an associate editor for the IEEE Transactions on Robotics (2009-2013) and for Soft Robotics (2018-2021). He was a guest editor for the Proceedings of IEEE, IEEE Transactions on Biomedical Engineering, Autonomous Robots, IEEE Robotics and Automation Magazine, and Biological Cybernetics. He has been the organizer of 7 international conferences (BioADIT2004, SAB2004, AMAM2005, BioADIT2006, LATSIS2006, SSRR2016, AMAM2019), and a program committee member of over 50 conferences.
Guido HaefeliTeaching & PhD PhD Students Federico Ronchetti, Gauri Napoletano Past EPFL PhD Students as codirector Axel Kuonen, Olivier Göran Girard, Carina Trippl Courses Particle detection PHYS-440 The course will cover the physics of particle detectors. It will introduce the experimental techniques used in nuclear and particle physics. The lecture includes the interaction of particles with matter, scintillators, gas detectors, silicon detectors, detectors for particle ID and photo-detectors.
Tobias KippenbergTobias J. Kippenberg is Full Professor of Physics at EPFL and leads the Laboratory of Photonics and Quantum Measurement. He obtained his BA at the RWTH Aachen, and MA and PhD at the California Institute of Technology (Caltech in Pasadena, USA). From 2005- 2009 he lead an Independent Research Group at the MPI of Quantum Optics, and is at EPFL since. His research interest are the Science and Applications of ultra high Q microcavities; in particular with his research group he discovered chip-scale Kerr frequency comb generation (Nature 2007, Science 2011) and observed radiation pressure backaction effects in microresonators that now developed into the field of cavity optomechanics (Science 2008). Tobias Kippenberg is alumni of the “Studienstiftung des Deutschen Volkes”. For his invention of “chip-scale frequency combs” he received he Helmholtz Price for Metrology (2009) and the EFTF Young Investigator Award (2010). For his research on cavity optomechanics, he received the EPS Fresnel Prize (2009). In addition he is recipient of the ICO Prize in Optics (2014), the Swiss National Latsis award (2015), the German Wilhelm Klung Award (2015) and ZEISS Research Award (2018). He is fellow of the APS and OSA, and listed since 2014 in the Thomas Reuters highlycited.com in the domain of Physics. EDUCATION 2009: Habilitation (Venia Legendi) in Physics, Ludwig-Maximilians-Universität München 2004: PhD, California Institute of Technology (Advisor Professor Kerry Vahala) 2000: Master of Science (Applied Physics), California Institute of Technology 1998: BA in Physics, Technical University of Aachen (RWTH), Germany 1998: BA in Electrical Engineering, Technical University of Aachen (RWTH), Germany ACADEMIC POSITIONS 2013 - present: Full Professor EPFL 2010 - 2012: Associate Professor EPFL 2008 - 2010: Tenure Track Assistant Professor, Ecole Polytechnique Federale de Lausanne 2007 - present: Marie Curie Excellent Grant Team Leader, Max Planck Institute of Quantum Optics (Division of Prof.T.W. Hänsch) 2005 - present: Leader of an Independent Junior Research Group, Max Planck Institute 2005- present: Habilitant (Prof. Hänsch) Ludwig-Maximilians-Universität (LMU) 2005-2006: Postdoctoral Scholar, Center for the Physics of Information, California Institute of Technology 2000-2004: Graduate Research Assistant, California Institute of Technology PRIZES AND HONORS: ZEISS Research Award 2018 Fellow of the APS 2016 Klung-Wilhelmy Prize 2015 Swiss Latsis Prize 2014 Selected Thomson Reuters Highly Cited Researcher in Physics, 2014/2015 ICO Prize, 2013 EFTF Young Scientist Award (for "invention of microresonator based frequency combs") 2010 Fresnel Prize of the European Physical Society (for contributions to Optomechanics) 2009 Helmholtz Prize for Metrology (for invention of the monolithic frequency comb) 2009 1st Prize winner of the EU Contest for Young Scientists, Helsinki, Finland. Sept. 1996 Jugend forscht 1st Physics Prize at the German National Science Contest May 1996 FELLOWSHIPS Fellow of the German National Merit Foundation ("Studienstiftung des Deutschen Volkes") 1998-2002 Member of the Daimler-Chysler-Fellowship-Organization 1998-2002 Dr. Ulderup Fellowship 1999-2000 RESEARCH INTERESTS Experimental and theoretical research in photonics, notably high Q optical microcavities and their use in cavity quantum optomechanics and frequency metrology PUBLICATIONS AND OFTEN CITED METRICS*: >70 Publications in peer reviewed journals Researcher Google Profile: http://scholar.google.ch/citations?user=PRCbG2kAAAAJ&hl=en h-Index 54 (Google scholar H: 64, >25,000 citations) Thomson Reuters/Claravite List of Highly Cited Researchers (2014,2015,2016,2017) careful in its use: https://www.aps.org/publications/apsnews/201411/backpage.cfm KEY PUBLICATIONS AND REVIEWS: A. Ghadimi, et al. Elastic strain engineering for ultra high Q nanomechanical oscillators Science, (2018) Trocha, et al. Ultrafast distance measurements using soliton microresonator frequency combs Science, Vol. 359 (2018) [joint work with C. Koos] Pablo-Marin et al. Microresonator-based solitons for massively parallel coherent optical communications Nature (2017) [joint work with C. Koos] V. Brasch, et al. Photonic chip-based optical frequency comb using soliton Cherenkov radiation. Science, vol. 351, num. 6271 (2015) Aspelmeyer, M., Kippenberg, T. J. & Marquardt, F. Cavity optomechanics. Reviews of Modern Physics 86, 1391-1452, (2014) Wilson, D. J. et al. Measurement and control of a mechanical oscillator at its thermal decoherence rate. Nature (2014). Verhagen, E., Deleglise, S., Weis, S., Schliesser, A. & Kippenberg, T. J. Quantum-coherent coupling of a mechanical oscillator to an optical cavity mode. Nature 482, 63-67 (2012). Kippenberg, T. J., Holzwarth, R. & Diddams, S. A. Microresonator-based optical frequency combs. Science 332, 555-559, (2011). Weis, S. et al. Optomechanically induced transparency. Science 330, 1520-1523 (2010). Kippenberg, T. J. & Vahala, K. J. Cavity optomechanics: back-action at the mesoscale. Science 321, 1172-1176, (2008). Del'Haye, P. et al. Optical frequency comb generation from a monolithic microresonator. Nature (2007) Schliesser, A., DelHaye, P., Nooshi, N., Vahala, K. & Kippenberg, T. Radiation Pressure Cooling of a Micromechanical Oscillator Using Dynamical Backaction. Physical Review Letters 97, (2006). Anna Fontcuberta i Morral2014 Associate Professor at the Institut des Matériaux, EPFL
2008 Assistant Professor Tenure Track at the Institut des Matériaux, EPFL
2009 Habilitation in Physics, Technische Universität München
2005-2010 Marie Curie Excellence Grant Team Leader at Walter Schottky Institut, Technische Universität München, on leave from Centre National de la Recherche Scientifique (CNRS, France)
2004-2005 Visiting Scientist at the California Institute of Technology, on leave from CNRS; Senior Scientist and co-founder of Aonex Technologies (a startup company for large area layer transfer of InP and Ge on foreign substrates for the main application of multi-junction solar cells)
2003 Permanent Research Fellow at CNRS, Ecole Polytechnique, France
2001-2002 Postdoctoral Scholar at the California Institute of Technology
Study of wafer bonding and hydrogen-induced exfoliation processes for integration of mismatched materials in views of photovoltaic applications
Sponsor: Professor Harry A. Atwater
1998-2001 PhD in Materials Science, Ecole Polytechnique
Study of polymorphous silicon: growth mechanisms, optical and structural properties. Application to Solar Cells and Thin Film Transistors
Advisor: Pere Roca i Cabarrocas
1997-1998 Diplôme dEtudes Approfondis (D.E.A.) in Materials Science at Université Paris XI, France .
1993-1997 BA in Physics at Universitat de Barcelona
Harm-Anton KlokExpertise
Polymer design at nanoscaleBiologically-inspired polymers
Mission
Research at the Laboratory of Polymer (LP) focuses on the development of novel advanced polymeric materials with potential applications in optics, electronics or medicine. The philosophy is that precise control over nanoscale structure is an important prerequisite to tailor polymer properties. To this end, a “bottom-up” approach is followed, which starts with designing a new material at the molecular level, in order to be able to pr
Olivier SchneiderAfter his thesis defense in particle physics in 1989 at University of Lausanne, Olivier Schneider joins LBL, the Lawrence Berkeley Laboratory (California), to work on the CDF experiment at the Tevatron in Fermilab (Illinois), first as a research fellow supported by the Swiss National Science Foundation, and later as a post-doc at LBL. He participates in the construction and commissioning of the first silicon vertex detector to operate successfully at a hadron collider; this detector enabled the discovery of the sixth quark, named "top". Since 1994, he comes back to Europe and participates in the ALEPH experiment at CERN's Large Electron-Positron Collider, as CERN fellow and then as CERN scientific staff. He specializes in heavy flavour physics. In 1998, he becomes associate professor at University of Lausanne, then extraordinary professor at the Swiss Institute of Technology Lausanne (EPFL) in 2003, and finally full professor at EPFL in 2010. Having worked since 1997 on the preparation of the LHCb experiment at CERN's Large Hadron Collider, which started operation in 2009, he is now analyzing the first data. He also contributes since 2001 to the exploitation of the data recorded at the Belle experiment (KEK laboratory, Tsukuba, Japan). These two experiments study mainly the decays of hadrons containing a b quark, as well CP violation, i.e. the non-invariance under the symmetry between matter and antimatter.
Vassily HatzimanikatisDr. Vassily Hatzimanikatis is currently Associate Professor of Chemical Engineering and Bioengineering at Ecole Polytechnique Federale de Lausanne (EPFL), in Lausanne, Switzerland. Vassily received a PhD and an MS in Chemical Engineering from the California Institute of Technology, and his Diploma in Chemical Engineering from the University of Patras, in Greece. After the completion of his doctoral studies, he held a research group leader position at the Swiss Federal Institute of Technology in Zurich (ETHZ), Switzerland. Prior to joining EPFL, Vassily worked for three years in DuPont, Cargill, and Cargill Dow, and he has been assistant professor at Northwestern University, at Illinois, USA.
Vassilys research interests are in the areas of computational systems biology, biotechnology, and complexity. He is associate editor of the journals Biotechnology & Bioengineering, Metabolic Engineering and Integrative Biology, and he serves on the editorial advisory board of the journals Bioprocess and Biosystems Engineering, Journal of Chemical Technology and Biotechnology, and Industrial Biotechnology. He has written over 70 technical publications and he is co-inventor in three patents and patent applications.
Vassily is a fellow of the American Institute for Medical and Biological Engineering (2010), he was a DuPont Young Professor (2001-2004), and he has also received the Jay Bailey Young Investigator Award in Metabolic Engineering (2000), and the ACS Elmar Gaden Award (2011).
Pierre DillenbourgA former teacher in elementary school, Pierre Dillenbourg graduated in educational science (University of Mons, Belgium). He started his research on learning technologies in 1984. In 1986, he has been on of the first in the world to apply machine learning to develop a self-improving teaching system. He obtained a PhD in computer science from the University of Lancaster (UK), in the domain of artificial intelligence applications for education. He has been assistant professor at the University of Geneva. He joined EPFL in 2002. He has been the director of Center for Research and Support on Learning and its Technologies, then academic director of Center for Digital Education, which implements the MOOC strategy of EPFL (over 2 million registrations). He is full professor in learning technologies in the School of Computer & Communication Sciences, where he is the head of the CHILI Lab: "Computer-Human Interaction for Learning & Instruction ». He is the director of the leading house DUAL-T, which develops technologies for dual vocational education systems (carpenters, florists,...). With EPFL colleagues, he launched in 2017 the Swiss EdTech Collider, an incubator with 80 start-ups in learning technologies. He (co-)-founded 4 start-ups, does consulting missions in the corporate world and joined the board of several companies or institutions. In 2018, he co-founded LEARN, the EPFL Center of Learning Sciences that brings together the local initiatives in educational innovation. He is a fellow of the International Society for Learning Sciences. He currently is the Associate Vice-President for Education at EPFL.
Herbert SheaExpertise
soft robotics, wearable haptics, electrostatic actuators, EHD
Mission
My lab develops flexible polymer-based actuators for a wide range of applications including haptics and soft robotics. More info at https://www.epfl.ch/labs/lmts/
Links from EPFL-LMTS Lab webpage People Research ActivitiesPublications TeachingPublications and Conference papers Link to my lab Education PhD | Physics 1997 – 1997 Harvard University MA | Physics 1993 – 1993 Harvard University 