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Nikolaos Stergiopoulos

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Related publications (229)

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The effect of the elongation of the proximal aorta on the estimation of the aortic wall distensibility

Nikolaos Stergiopoulos, Vasiliki Bikia, Bram Trachet, Georgios Rovas, Stamatia Zoi Pagoulatou, Mauro Ferraro

The compliance of the proximal aortic wall is a major determinant of cardiac afterload. Aortic compliance is often estimated based on cross-sectional area changes over the pulse pressure, under the assumption of a negligible longitudinal stretch during the ...

2021

Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva

Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...

Nature Research2020

Design and computational optimization of compliance-matching aortic grafts

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas

Introduction: Synthetic vascular grafts have been widely used in clinical practice for aortic replacement surgery. Despite their high rates of surgical success, they remain significantly less compliant than the native aorta, resulting in a phenomenon calle ...

FRONTIERS MEDIA SA2023

On the Estimation of Total Arterial Compliance from Aortic Pulse Wave Velocity

Nikolaos Stergiopoulos, Orestis Vardoulis

Total arterial compliance (C (T)) is a main determinant of cardiac afterload, left ventricular function and arterio-ventricular coupling. C (T) is physiologically more relevant than regional aortic stiffness. However, direct, in vivo, non-invasive, measure ...

Springer US2012

Methodologies to assess blood flow in cerebral aneurysms: Current state of research and perspectives

Nikolaos Stergiopoulos, Mohamed Farhat, Philippe Reymond

With intracranial aneurysms disease bringing a weakened arterial wall segment to initiate, grow and potentially rupture an aneurysm, current understanding of vessel wall biology perceives the disease to follow the path of a dynamic evolution and increasing ...

2009

Prognostic Implications of the Novel Pulmonary Hypertension Definition in Patients with Aortic Stenosis after Transcatheter Valve Replacement

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Introduction: Pulmonary hypertension (PH), traditionally defined as a mean pulmonary artery pressure (PAP) >= 25 mmHg, is associated with poor outcomes in patients undergoing a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS). ...

MDPI2022

Effect of an abdominal aortic aneurysm on wave reflection in the aorta

Nikolaos Stergiopoulos

Despite extensive attention to abdominal aortic aneurysm (AAA) in the biomedical engineering community, its effect on aortic hemodynamics and arterial wave reflection has not been addressed before. We used experimental and numerical methods, relying on a r ...

2008

Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt

Nikolaos Stergiopoulos

Venous anastomotic intimal hyperplasia (IH) observed in the arteriovenous shunt (AVS) has been associated with disturbed hemodynamics. This study aims to correlate hemodynamics with wall histology and wall mechanics by examining the flow field in AVS with ...

2010

Performance and safety of treatment options for erectile dysfunction in patients with spinal cord injury: A review of the literature

Nikolaos Stergiopoulos, Rodrigo Araujo Fraga Da Silva, Mikaël Nils Sturny

Background For a large proportion of patients with spinal cord injury, sexuality and reproduction are important issues. However, sparse data exist regarding available treatment options for this patient population. Objectives We sought to review performance ...

WILEY2020

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...

Lippincott Williams & Wilkins2023

Validation of a one-dimensional model of the systemic arterial tree

Nikolaos Stergiopoulos, Philippe Reymond, Fabrice Merenda

A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughou ...

2009

Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis

Nikolaos Stergiopoulos

Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antag ...

Schattauer Gmbh-Verlag Medizin Naturwissenschaften2016

Time course of flow-induced adaptation of carotid artery biomechanical properties, structure and zero-stress state in the arteriovenous shunt

Nikolaos Stergiopoulos

Numerous studies have provided evidence of diameter adaptation secondary to flow-overload. but with ambiguous findings vis a vis other morphological parameters and information on the biomechanical aspects of arterial adaptation is rather incomplete. We exa ...

2012

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Nikolaos Stergiopoulos

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

2019

Aortic Impedance and Total Arterial Compliance from Regional Pulse Wave Velocities

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Stamatia Zoi Pagoulatou

Background In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for invasive methods to access simultaneous recordings of aortic pressure and flow, wall thickness, and cross-sectional ...

2020

In Silico Validation of Non-Invasive Arterial Compliance Estimation and Potential Determinants of its Variability

Nikolaos Stergiopoulos, Vasiliki Bikia

Arterial compliance (AC) is an important cardiovascular parameter characterizing mechanical properties of arteries. AC is significantly influenced by arterial wall structure and vasomotion, and it markedly influences cardiac load. A new method, based on a ...

2024

An Animal-Specific FSI Model of the Abdominal Aorta in Anesthetized Mice

Nikolaos Stergiopoulos, Bram Trachet

Recent research has revealed that angiotensin II-induced abdominal aortic aneurysm in mice can be related to medial ruptures occurring in the vicinity of abdominal side branches. Nevertheless a thorough understanding of the biomechanics near abdominal side ...

Springer2015

Systolic Hypertension Mechanisms: Effect of Global and Local Proximal Aorta Stiffening on Pulse Pressure

Nikolaos Stergiopoulos, Philippe Reymond

Decrease in arterial compliance leads to an increased pulse pressure, as explained by the Windkessel effect. Pressure waveform is the sum of a forward running and a backward running or reflected pressure wave. When the arterial system stiffens, as a result ...

Springer US2012

On the in-series and in-parallel contribution of elastin assessed by a structure-based biomechanical model of the arterial wall

Nikolaos Stergiopoulos, Sylvain Roy

Earlier experimental work on decellularized arteries revealed the existence of significant residual stresses within the arterial wall, which are released upon chemical removal of vascular smooth muscle in normal arteries causing substantial radial expansio ...

2008

Incidence, severity, mortality, and confounding factors for dissecting AAA detection in angiotensin II-infused mice: a meta-analysis

Nikolaos Stergiopoulos, Bram Trachet

Aims While angiotensin II-infused mice are the most popular model for preclinical aneurysm research, representative data on incidence, severity, and mortality of dissecting abdominal aortic aneurysms (AAAs) have never been established, and the influence of ...

Oxford University Press2015