Nikolaos Stergiopoulos

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Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three direct ...

Transcatheter aortic valve replacement (TAVR) is increasingly used to treat severe aortic stenosis (AS) patients. However, little is known regarding the direct effect of TAVR on the ventricular-aortic interaction. In the present study, we aimed to investig ...

It has been suggested that the shape of the normalized time-varying elastance curve [E(n)(t(n))] is conserved in different cardiac pathologies. We hypothesize, however, that the E(n)(t(n)) differs quantitatively after myocardial infarction (MI). Sprague-Da ...

In aortic valve regurgitation (AR), aortic leak severity modulates left ventricle (LV) arterial system interaction. The aim of this study was to assess (1) how arterial elastance (E(a)), calculated as the ratio of LV end-systolic pressure and stroke volume, relates to arterial properties and leak severity and (2) the validity of E(a)/E(max) (with E(max) the slope of the end-systolic pressure-volume relation) as a heart-arterial coupling parameter in AR.

Precis: In this study, we report clinical results after implantation of an adjustable glaucoma drainage device. The intraocular pressure (IOP) profile was efficiently controlled postoperatively as the resistance to aqueous humor outflow was finely adjusted ...

Background Neutrophil-mediated inflammation was recently identified as an active contributor to athero-progression. Therapeutic strategies inhibiting neutrophil degranulation or recruitment were hypothesized to positively impact on plaque vulnerability. In ...

The arterial system can be modelled by means of distributed analogs and by lumped parameter representations, such as the Windkessel. The distributed models, together with biological data, lead to the explanation of arterial function in terms of pressure and flow. The lumped parameter models form the basis of arterial compliance and characteristic impedance estimation. They also make comparison between mammals possible and it could be shown that input impedance, when scaled, is similar in mammals.

Shear stress has been shown to influence endothelial cell gene expression and morphology. In particular, low and bi-directional shear stress, mimicking conditions at plaque-prone areas, down-regulates the expression of several atheroprotective genes, and u ...

The three-dimensional biomechanical behavior of the vascular wall is best described by means of strain energy functions. Significant effort has been devoted lately in the development of structure-based models of the vascular wall, which account for the ind ...

The study verifies the development of active axial stress in the wall of mouse aorta over a range of physiological loads when the smooth muscle cells are stimulated to contract. The results obtained show that the active axial stress is virtually independen ...

Stroke volume (SV) is a major indicator of cardiovascular function, providing essential information about heart performance and blood flow adequacy. Accurate SV measurement is particularly important for assessing patients with heart failure, managing patie ...

Background: Clinical and experimental evidence regarding the influence of heart rate (HR) on arterial stiffness and its surrogate marker carotid-to-femoral pulse wave velocity (cf-PWV) is conflicting. We aimed to evaluate the effect of HR on cf-PWV measure ...

Purpose: To assess the efficacy and safety of a glaucoma procedure to control intraocular pressure (IOP) using the adjustable eyeWatch glaucoma drainage device compared with Ahmed glaucoma valve (AGV) in refractory glaucoma. Patients and Methods: Monocentr ...

Objective: Vascular prostheses currently used in vascular surgery do not have the same mechanical properties as human arteries. This computational study analyses the mechanisms by which grafts, placed in the ascending aorta (proximal) and descending aorta ...

The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system. Furthermore, clear compelling evidence indicates that this system is an essential modulator of penile erectile. Higher levels of angiotensin (Ang) II, the main component of ...

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

Apparatus and methods are provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device operates on the principles of a Starling resistor, and includes a housing, a deformable structure and a spring mounte ...

A device (100) is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device (100) includes a housing shell (101) defining a cavity (107) between a first end (102) and a second end (104) of the housing ...

An Implantable delivery device comprising at least a body (1), an inlet (2 17 46) and an outlet (3 18 47) and actuating means, wherein the actuating means comprise at least an actuator displacing a piston (6 21 32) in a rotating cylinder (4 19 31) forming ...

Compliant vascular grafts for implantation in the vasculature are provided. The compliant vascular grafts are designed to expand longitudinally and radially within a blood vessel, such as an artery, and is expected to be particularly well suited for treati ...

Nikolaos Stergiopoulos

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Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine

Acute effects of transcatheter aortic valve replacement on the ventricular-aortic interaction

The effect of a myocardial infarction on the normalized time-varying elastance curve

Arterial elastance and heart-arterial coupling in aortic regurgitation are determined by aortic leak severity

Initial Clinical Results of the eyeWatch: a New Adjustable Glaucoma Drainage Device Used in Refractory Glaucoma Surgery

Alamandine abrogates neutrophil degranulation in atherosclerotic mice

Models of the arterial tree

Oscillatory shear stress and reduced compliance impair vascular functions

A structural model of the venous wall considering elastin anisotropy

Active axial stress in mouse aorta

Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data

The impact of heart rate on pulse wave velocity: an in-silico evaluation

Comparison Between the eyeWatch Device and the Ahmed Valve in Refractory Glaucoma

Impact of Aortic Grafts on Arterial Pressure: A Computational Fluid Dynamics Study

The Role of the Renin-Angiotensin System in Erectile Dysfunction: Present and Future

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Apparatus for treating excess intraocular fluid

Apparatus for treating excess intraocular fluid having an elastic membrane

Implantable drug delivery device

Compliant vascular grafts and methods of use