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Thomas Rizzo

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Related publications (100)

Using SLIM-Based IMS-IMS Together with Cryogenic Infrared Spectroscopy for Glycan Analysis

Thomas Rizzo, Ahmed Ben Faleh, Natalia Yalovenko, Stephan Warnke, Priyanka Bansal, Ali H Abikhodr, Vasyl Yatsyna

The isomeric heterogeneity of glycans poses a great challenge for their analysis. While combining ion mobility spectrometry (IMS) with tandem mass spectrometry is a powerful means for identifying and characterizing glycans, it has difficulty distinguishing ...

2020

How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans?

Thomas Rizzo, Ahmed Ben Faleh, Robert Paul Pellegrinelli, Stephan Warnke, Eduardo Carrascosa Casado, Lei Yue

: Despite the essential role that glycans play in many biological processes, their isomeric com-plexity makes their structural determination partic-ularly challenging. Tandem mass spectrometry has played a central role in glycan analysis, and recent work h ...

2020

Combining Cryogenic Infrared Spectroscopy with Selective Enzymatic Cleavage for Determining Glycan Primary Structure

Thomas Rizzo, Robert Paul Pellegrinelli, Eduardo Carrascosa Casado

Given the biological relevance and intrinsic structural complexity of glycans, increasing efforts are being directed towards developing a general glycan database that includes information from different analytical methods. As recently demonstrated, cryogen ...

2020

UV and IR Spectroscopy of Transition Metal–Crown Ether Complexes in the Gas Phase: Mn2+(benzo-15-crown-5)(H2O)0–2

Thomas Rizzo, Yoshiya Inokuchi

Ultraviolet photodissociation (UVPD) and IR–UV double-resonance spectroscopy are performed for bare and microhydrated complexes of Mn2+(benzo-15-crown-5), Mn2+(B15C5)(H2O)n (n = 0–2), under cold (∼10 K) gas-phase conditions. Density functional theory (DFT) ...

2019

Cryogenic Ion Spectroscopy for Identification of Monosaccharide Anomers

Thomas Rizzo, Valeriu Scutelnic

We combine conformer-selective, cryogenic infrared spectroscopy, quantum mechanical computations, and 18O substitution at the reducing end to determine the structural preferences of protonated glucosamine in the gas phase. Cryogenic infrared-infrared (IR-I ...

2019

Combining ultra-high resolution ion-mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions

Thomas Rizzo, Ahmed Ben Faleh, Robert Paul Pellegrinelli, Natalia Yalovenko, Stephan Warnke

Double-resonance spectroscopic schemes in combination with cryogenic ion traps are the go-to techniques when isomer-specific high-resolution spectra are required for analysis of molecular ions. Their limitation lies in the requirement for well-resolved, is ...

2019

HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Manuel Bauer, Luca Rossi, Thomas Rizzo, François Robert, Jean-Michel Sallese, Pierluigi Bruzzone, Mikhail Chapochnikov, Bernhard Auchmann, Jeffrey Alan Hubbell, Alban Sublet, Mathias Oleg Knecht, Yu Bai, Jorg Wenninger, Marc-Olivier Sauvain, Tatiana Pieloni, Leonid Rivkin, Hua Zhang, Xavier Buffat, Mingkui Wang, Andrea Wulzer, Martin Vogel, Sandra Aumon, Alexandra Sarabando de Carvalho, Giuseppe Montenero, Marco Drewes, Giovanni Migliorati, Florian Patrick Marie Daniel De la Barre De Nanteuil, Doohyun Kim, Frank Zimmermann, José Luis Abelleira Fernández, Alexej Grudiev, Fabio Avino, Massimo Giovannozzi, Patrik Gonçalves Jorge, Francesco Cerutti, Javier Barranco Garcia, Roberto Contino, Eva Maria Rodriguez Franco, Rudiger Schmidt, Claudia Tambasco, , , , , , , , , , , , , , , , ,

Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion Mobility Spectrometry and Cryogenic Ion Spectroscopy

Thomas Rizzo, Ahmed Ben Faleh, Valeriu Scutelnic, Stephan Warnke

The analysis of carbohydrates, or glycans, is challenging for established structure-sensitive gas-phase methods. The multitude of possible stereo-, regio- and structural isomers make them substantially more complex to ana-lyze than DNA or proteins, and no ...

2019

FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

Manuel Bauer, Luca Rossi, Thomas Rizzo, François Robert, Jean-Michel Sallese, Pierluigi Bruzzone, Benedikt Moser, Mikhail Chapochnikov, Bernhard Auchmann, Jeffrey Alan Hubbell, Nicolas Andreini, Alban Sublet, Anatole von Lilienfeld, Mathias Oleg Knecht, Yu Bai, Jorg Wenninger, Michele Cascella, Marc-Olivier Sauvain, Tatiana Pieloni, Pablo Marcelo Perez Garcia, Rui Ning Wang, Leonid Rivkin, Hua Zhang, Xavier Buffat, Mingkui Wang, Andrea Wulzer, Martin Vogel, Nathalie Sophie Adeline Serra, Sandra Aumon, Alexandra Sarabando de Carvalho, Roberto Franceschini, Karin Irmgard Löw, Lucia Jimenez Rojo, Jie Gao, Giuseppe Montenero, Marco Drewes, Craig Nowell, Peter Michael Vogel, Shourya Dutta Gupta, Jairo Camilo Quijano Perez, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

High-throughput cryogenic spectroscopy for glycan analysis

Thomas Rizzo, Ahmed Ben Faleh, Valeriu Scutelnic, Stephan Warnke

A method for analyzing a plurality of molecules with cryogenic vibrational spectroscopy including the steps of providing a packet of molecules in a ionized form, injecting the packet into an ion mobility section, spatially separating the ions of the packet ...

2019

Controlling internal degrees: general discussion

Thomas Rizzo, Robert Benny Gerber

ROYAL SOC CHEMISTRY2019

Combining Ultrahigh-Resolution Ion-Mobility Spectrometry with Cryogenic Infrared Spectroscopy for the Analysis of Glycan Mixtures

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke

The isomeric complexity of glycans make their analysis by traditional techniques particularly challenging. While the recent combination of ion mobility spectrometry (IMS) with cryogenic IR spectroscopy has demonstrated promise as a new tech-nique for glyca ...

2019

Going large(r): general discussion

Thomas Rizzo, Robert Benny Gerber

ROYAL SOC CHEMISTRY2019

Combining Ion Mobility and Cryogenic Spectroscopy for Structural and Analytical Studies of Biomolecular Ions

Thomas Rizzo, Michael Zachary Kamrath

Ion mobility spectrometry (IMS) has become a valuable tool in biophysical and bioanalytical chemistry because of its ability to separate and characterize the structure of gas-phase biomolecular ions on the basis of their collisional cross section (CCS). It ...

2018

Microhydration of Dibenzo-18-Crown-6 Complexes with K+, Rb+, and Cs+ Investigated by Cold UV and IR Spectroscopy in the Gas Phase

Thomas Rizzo, Yoshiya Inokuchi

In this Article, we examine the hydration structure of dibenzo-18-crown-6 (DB18C6) complexes with K+, Rb+, and Cs+ ion in the gas phase. We measure well-resolved UV photodissociation (UVPD) spectra of K+·DB18C6·(H2O)n, Rb+·DB18C6·(H2O)n, and Cs+·DB18C6·(H2 ...

2018

Can Mutational Analysis Be Used To Assist Structure Determination of Peptides?

Thomas Rizzo, Liudmila Voronina, Chiara Masellis, Valeriu Scutelnic

Mutational analysis is widely used to study the relationship between sequence and structure of proteins and peptides. It is often assumed that substituting a proline with another amino acid "locks" the peptide bond in the trans conformation, allowing only ...

2018

Infrared Spectroscopy as a Probe of Electronic Energy Transfer

Thomas Rizzo, Aleksandra Zabuga, Antonio Prlj, Valeriu Scutelnic

We have combined electronic and vibrational spec- troscopy in a cryogenic ion trap to produce highly resolved, conformer-selective spectra for the ground and excited states of a peptide containing two chromophores. These spectra permit us to determine the ...

2018

Cryogenic IR spectroscopy combined with ion mobility spectrometry for the analysis of human milk oligosaccharides

Thomas Rizzo, Michael Zachary Kamrath, Chiara Masellis, Neelam Khanal

We report here our combination of cryogenic, messenger-tagging, infrared (IR) spectroscopy with ion mobility spectrometry (IMS) and mass spectrometry (MS) as a way to identify and analyze a set of human milk oligosaccharides (HMOs) ranging from trisacchari ...

2018

A method for characterizing polysaccharides

Thomas Rizzo, Michael Zachary Kamrath, Chiara Masellis, Neelam Khanal

A method for a structural characterization of polysaccharides, comprising steps of characterizing a polysaccharide by physical measurements comprising a determination of a mass of the polysaccharide by means of mass spectrometry, a further determination of ...

2018

The Structure of the Protonated Serine Octamer

Thomas Rizzo, Ursula Röthlisberger, Aurelien Stephen Arnaud Gregor, Marta Andreia Da Silva Perez, Valeriu Scutelnic, Stephan Warnke, Carsten Baldauf

The amino acid serine has long been known to form a protonated “magic-number” cluster containing eight monomer units that shows an unusually high abundance in mass spectra and has a remarkable homochiral preference. Despite many experimental and theoretica ...

2018

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Michael Schenk

Yi Zhang

Georgi Gorine

Agnieszka Chmielinska

Lorena Gonçalves de Alcântara e Freitas Krikler

Léon Van Riesen-Haupt

In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider ...

2019

Giovanni Migliorati

Andrea Thamm

Florian Patrick Marie Daniel De la Barre De Nanteuil

Andrey Denisov

Doohyun Kim

Frank Zimmermann

José Luis Abelleira Fernández

Alexej Grudiev

Philippe Schwaller

Fabio Avino

Darius Constantin Merk

Massimo Giovannozzi

Arturo Rivetti

Patrik Gonçalves Jorge

Francesco Cerutti

Ting-Yu Lee

Dragos-Adrian Seredinschi

Leonid Kahle

Juan Federico Esteban Müller

Javier Barranco Garcia

Roberto Contino

Eva Maria Rodriguez Franco

Beat Mueller

Rudiger Schmidt

Claudia Tambasco

Abdel Perez Hernandez

Shang-Jung Wu

José Luis Rivera Gutiérrez

Agnieszka Chmielinska

Lorena Gonçalves de Alcântara e Freitas Krikler

Candice Megan T Young

Rafael Amorim Leandro De Castro Amoedo

Xingyu Wu

Amirhossein Saba Shirvan

Wanderson Oliveira Da Silva

Mukesh Kumar Tripathi

Léon Van Riesen-Haupt

We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, ...

2019