Michael Amrhein

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Related publications (30)

Measurement-Based Drift Correction in Spectroscopic Calibration Models

Michael Amrhein, Dominique Bonvin, Pamandeep Singh Gujral

Correct prediction of analyte concentrations from a new spectrum without drift is possible provided the spectrum lies in the row space spanned by the calibration spectra (space-inclusion condition). However, this condition may be violated as on-line spectr ...

cemagref Languedoc Roussillon2008

Rank analysis of spectral reaction data for factor-analytical methods

Michael Amrhein, Dominique Bonvin, Nirav Pravinbhai Bhatt

Cemagref Languedoc Roussillon2008

Rank augmentation of spectral reaction data using calorimetric and gas consumption data

Michael Amrhein, Dominique Bonvin, Nirav Pravinbhai Bhatt

Cemagref Languedoc Roussillon2008

On-Line Recalibration of Spectral Measurements Using Metabolite Injections and Dynamic Orthogonal Projection

Michael Amrhein, Urs von Stockar, Michal Dabros, Pamandeep Singh Gujral

Spectrometers are enjoying increasing popularity in bioprocess monitoring due to their non-invasiveness and in-situ sterilizability. Their on-line applicability and high measurement frequency create an interesting opportunity for process control and optimi ...

2007

Automatic detection of reaction start/endpoints in chemical and biotechnological reaction systems

Michael Amrhein, Simon Crelier

A classification methodology for the automatic detection of start- and endpoints of chemical and biotechnological reaction systems from spectral reaction data is proposed. In the calibration phase, several batch experiments must be conducted covering the e ...

2007

Scale-up of batch processes via decentralized control

Michael Amrhein, Dominique Bonvin, Alejandro Gabriel Marchetti, Benoît Chachuat

The economic environment in the specialty chemicals industry requires short times to market and thus the ability to develop new products and processes very rapidly. This, in turn, calls for large scale-ups from laboratory to production. Due to scale-relate ...

2006

Information extraction from the Evolving Factor Analysis

Michael Amrhein, Simon Crelier

The goal of our project (HES-SO n°11246) is to develop chemometric methods that enhance the development of chemical reactions. Semi-batch experiments are performed using a fully automated chemical reactor. Real-time analytical data, infrared (IR) spectra f ...

2005

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