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This lecture covers the concept of planetary boundaries, focusing on biodiversity and sustainability. It discusses the safe operating space for humanity on Earth, the environmental limits, and the influence of crossing boundaries. The framework aims to guide human development in a changing planet by identifying key boundaries and their impact on Earth's system. Various proxies, such as diatoms and forams, are used to infer past climates, while the lecture also delves into the impact of climate change, genetic diversity, and novel entities on the planet's sustainability.