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This lecture covers the vulnerability of microelectronics to the harsh space environment, including space radiations, radiation effects on microelectronics, and mitigation techniques. Topics include the impact of energetic particles, radiation belts, magnetosphere shielding, and the South Atlantic Anomaly. The instructor discusses the effects of solar wind, galactic cosmic rays, and the variability of Van Allen Belts on spacecraft and microelectronics. The presentation also addresses the classification of radiations, their effects on semiconductor structures, and the consequences of radiation on microelectronics components.