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This lecture introduces Physically-based Differentiable Rendering, a technique used in the Realistic Graphics Lab at EPFL. The instructor presents the motivation behind this approach, its applications in scene description, forward and inverse rendering, and 3D scene reconstruction. The lecture also covers the use of differentiable rendering in shape reconstruction, geometry representation using meshes and signed distance functions, and a specific method involving ray intersection with Signed Distance Functions. Finally, the instructor concludes by highlighting the feasibility of differentiating complex light transport effects and its potential applications in various domains beyond traditional graphics and vision problems.