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This lecture explores the mechanical properties and strengthening mechanisms of alloys, focusing on the thermo-mechanical loading of Ni superalloys, plastic deformation, dislocations, slip systems, and various strengthening mechanisms such as dislocation hardening, solid solution strengthening, grain boundary strengthening, particle strengthening, and grain orientation strengthening. It also covers topics like cyclic deformation, fatigue, high temperature plasticity, creep, creep curves, creep deformation mechanisms, high temperature deformation, and thermo-mechanical fatigue.