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Lecture

Tutorial: Using Differential Search

Description

This lecture provides a tutorial on using differential search in the context of the multi-scale brain, focusing on mouse brain development, connectivity, diversity, and human brain. It covers topics such as glioblastoma, sleep, and the Allen Brain Atlas.

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Related concepts (21)

Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

Brain mapping

Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. According to the definition established in 2013 by Society for Brain Mapping and Therapeutics (SBMT), brain mapping is specifically defined, in summary, as the study of the anatomy and function of the brain and spinal cord through the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology.

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

Sleep

Sleep is a state of reduced mental and physical activity in which consciousness is altered and sensory activity is inhibited to a certain extent. During sleep, there is a decrease in muscle activity, and interactions with the surrounding environment. While sleep differs from wakefulness in terms of the ability to react to stimuli, it still involves active brain patterns, making it more reactive than a coma or disorders of consciousness. Sleep occurs in repeating periods, during which the body alternates between two distinct modes: REM and non-REM sleep.

Sleep deprivation

Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support decent alertness, performance, and health. It can be either chronic or acute and may vary widely in severity. Acute sleep deprivation is when an individual sleeps less than usual or does not sleep at all for a short period of time – normally lasting one to two days but tends to follow the sleepless pattern for longer with no outside factors in play.

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