Search engineA search engine is a software system that finds web pages that match a web search. They search the World Wide Web in a systematic way for particular information specified in a textual web search query. The search results are generally presented in a line of results, often referred to as search engine results pages (SERPs). The information may be a mix of hyperlinks to web pages, images, videos, infographics, articles, and other types of files. Some search engines also mine data available in databases or open directories.
HumanHumans, or modern humans (Homo sapiens), are the most common and widespread species of primate. A great ape characterized by their hairlessness, bipedalism, and high intelligence, humans have a large brain and resulting cognitive skills that enable them to thrive in varied environments and develop complex societies and civilizations. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states.
Archaic humansA number of varieties of Homo are grouped into the broad category of archaic humans in the period that precedes and is contemporary to the emergence of the earliest early modern humans (Homo sapiens) around 300 ka. Among the earliest remains of H. sapiens are Omo-Kibish I (Omo I) from southern Ethiopia ( 195 or 233 ka), the remains from Jebel Irhoud in Morocco (about 315 ka) and Florisbad in South Africa (259 ka). The term typically includes H. antecessor, H. bodoensis, Denisovans (H. denisova), H.
Protein superfamilyA protein superfamily is the largest grouping (clade) of proteins for which common ancestry can be inferred (see homology). Usually this common ancestry is inferred from structural alignment and mechanistic similarity, even if no sequence similarity is evident. Sequence homology can then be deduced even if not apparent (due to low sequence similarity). Superfamilies typically contain several protein families which show sequence similarity within each family.
Protein structure predictionProtein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its secondary and tertiary structure from primary structure. Structure prediction is different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by computational biology; and it is important in medicine (for example, in drug design) and biotechnology (for example, in the design of novel enzymes).
Timeline of human evolutionThe timeline of human evolution outlines the major events in the evolutionary lineage of the modern human species, Homo sapiens, throughout the history of life, beginning some 4 billion years ago down to recent evolution within H. sapiens during and since the Last Glacial Period. It includes brief explanations of the various taxonomic ranks in the human lineage. The timeline reflects the mainstream views in modern taxonomy, based on the principle of phylogenetic nomenclature; in cases of open questions with no clear consensus, the main competing possibilities are briefly outlined.
Post-translational modificationPost-translational modification (PTM) is the covalent process of changing proteins following protein biosynthesis. PTMs may involve enzymes or occur spontaneously. Proteins are created by ribosomes translating mRNA into polypeptide chains, which may then change to form the mature protein product. PTMs are important components in cell signalling, as for example when prohormones are converted to hormones. Post-translational modifications can occur on the amino acid side chains or at the protein's C- or N- termini.
Homo erectusHomo erectus (ˌhoʊmoʊ_ə'rɛktəs; meaning "upright man") is an extinct species of archaic human from the Pleistocene, with its earliest occurrence about 2 million years ago. Its specimens are among the first recognizable members of the genus Homo. Several human species, such as H. heidelbergensis and H. antecessor, appear to have evolved from H. erectus, and Neanderthals, Denisovans, and modern humans are in turn generally considered to have evolved from H. heidelbergensis. H.
Protein foldingProtein folding is the physical process where a protein chain is translated into its native three-dimensional structure, typically a "folded" conformation, by which the protein becomes biologically functional. Via an expeditious and reproducible process, a polypeptide folds into its characteristic three-dimensional structure from a random coil. Each protein exists first as an unfolded polypeptide or random coil after being translated from a sequence of mRNA into a linear chain of amino acids.
Protein familyA protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be confused with family as it is used in taxonomy. Proteins in a family descend from a common ancestor and typically have similar three-dimensional structures, functions, and significant sequence similarity.
Homo ergasterHomo ergaster is an extinct species or subspecies of archaic humans who lived in Africa in the Early Pleistocene. Whether H. ergaster constitutes a species of its own or should be subsumed into H. erectus is an ongoing and unresolved dispute within palaeoanthropology. Proponents of synonymisation typically designate H. ergaster as "African Homo erectus" or "Homo erectus ergaster". The name Homo ergaster roughly translates to "working man", a reference to the more advanced tools used by the species in comparison to those of their ancestors.
Quadrupole mass analyzerIn mass spectrometry, the quadrupole mass analyzer (or quadrupole mass filter) is a type of mass analyzer originally conceived by Nobel laureate Wolfgang Paul and his student Helmut Steinwedel. As the name implies, it consists of four cylindrical rods, set parallel to each other. In a quadrupole mass spectrometer (QMS) the quadrupole is the mass analyzer - the component of the instrument responsible for selecting sample ions based on their mass-to-charge ratio (m/z).
