Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Drug-Induced Liver Injury (DILI): Mechanisms and Mitigation

Related lectures (32)

Drug Metabolism: Xenobiotics and Enzymes

Explores drug metabolism, focusing on xenobiotics, enzymes, biotransformation reactions, and factors affecting drug metabolism.

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Pharmacogenetics: Drug Response and Genetic Variability

Delves into pharmacogenetics, exploring genetic influences on drug response variability and metabolism.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Selective Drug Targeting Mechanisms

Explores selective drug targeting mechanisms, resistance development, tuberculosis incidence, BCR-ABL mutations, tyrosine kinase inhibitors, drug toxicity, interactions, and toxicology studies.

Metabolism and Hormones

Explores metabolic processes in different tissues and the role of hormones.

Metabolism Integration: Gluconeogenesis and Glycolysis

Discusses the integration of metabolic pathways, focusing on gluconeogenesis and glycolysis, and their hormonal regulation in maintaining glucose homeostasis.

Pharmacodynamics: Ligand-Receptor Interactions and Drug Effects

Explores ligand-receptor interactions, drug effects, modulation mechanisms, and factors influencing drug responses.

Nuclear Receptors: Drug Targets

Explores nuclear receptors, their role in drug pharmacology, and physiological functions in adipose tissue and glucose homeostasis.

Metabolism and Hormones

Explores tissue-specific metabolism, hormone regulation, and enzyme cascades in glucose and lipid metabolism.

Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.

Neuroepigenetics: Chromatin Structure & Inheritance

Delves into neuroepigenetics, covering chromatin structure, histone modifications, DNA methylation, and their impact on gene transcription and inheritance.

Deep Generative Models in Drug Discovery

Explores the application of deep generative models in drug discovery, focusing on designing small molecules and optimizing molecular structures.

Drug Targets: Adrenergic Signaling

Explores drug targets and adrenergic signaling, covering receptors, enzymes, and transporter proteins.

Regulation Mechanisms Overview

Covers phosphorylation, ubiquitinylation, methylation, and more in biological regulation.

Liver Detoxification: Bile Acids, Cholesterol, and Xenobiotics

Explores liver metabolism of bile acids, cholesterol, and xenobiotics, emphasizing detoxification processes and lipid transport.

Neuroepigenetics: Chromatin Structure and Regulation

Explores neuroepigenetics, focusing on chromatin structure, regulation, and epigenetic inheritance in neurodevelopment.

Drug Targets: Nuclear Receptors

Explores drug targets, particularly nuclear receptors like PPARy and pregnane X receptor, and their impact on endocrine signaling and drug pharmacokinetics.

Drug Targets: ligand-gated ion channels and kinase-linked receptors

Explores drug targets in ligand-gated ion channels and kinase-linked receptors, focusing on GABAA receptors, benzodiazepines, and insulin therapy.

Neuroepigenetics: Chromatin Regulation and Memory Formation

Delves into chromatin regulation's role in memory formation, genetic and epigenetic influences on learning, and the potential of HDAC inhibitors as cognitive enhancers.