Lecture

Life at Low Reynolds Number: Microorganisms' Adaptation and Propulsion

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In course

BIO-244: Physics of the cell

Living organisms evolve in a physical world: their cells respond to mechanics, electricity and light. In this course, we will describe the behavior and function of cells using physical principles. ...

Description

This lecture explores the challenges microorganisms face living at small scales, focusing on their evolution and adaptation mechanisms. It delves into the motility of bacteria, such as E. coli and V. alginolyticus, and discusses the significance of small-scale flows in biological systems. The instructor also covers the mucociliary clearance process in the lungs, emphasizing its role in the immune system. Additionally, the lecture addresses the propulsion mechanisms at the microscale, highlighting the importance of asymmetric body deformation for movement at low Reynolds numbers. Key concepts include the generation of propulsive forces and the comparison of inertial and viscous forces in microorganisms' locomotion.

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Instructor

Alexandre Louis André Persat

Expertise bacterial biophysics and bioengineeringmicrofluidicscellular biomechanics Teaching & PhD PhD Students Jann Lukas Ledergerber, Dea Mariette Müller, Marin Paul Geoffroy Marie Ollagnon, Han-Yi Huang, Alice Pellegrino, Shiro Otaki, Chia-Ni Tsai, Po-Long Hsiao Past EPFL PhD Students Lorenzo Anton-Louis Talà, Xavier Pierrat, Tamara Rossy, Alice Cont, Jeremy Wong, Sourabh Monnappa Kuppanda Jafri, Tania Distler Past EPFL PhD Students as codirector Gabriele Gambardella Courses Fluid mechanics (for SV)

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Related concepts (32)

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Spacecraft propulsion

Spacecraft propulsion is any method used to accelerate spacecraft and artificial satellites. In-space propulsion exclusively deals with propulsion systems used in the vacuum of space and should not be confused with space launch or atmospheric entry. Several methods of pragmatic spacecraft propulsion have been developed, each having its own drawbacks and advantages. Most satellites have simple reliable chemical thrusters (often monopropellant rockets) or resistojet rockets for orbital station-keeping and some use momentum wheels for attitude control.

Propulsion

Propulsion is the generation of force by any combination of pushing or pulling to modify the translational motion of an object, which is typically a rigid body (or an articulated rigid body) but may also concern a fluid. The term is derived from two Latin words: pro, meaning before or forward; and pellere, meaning to drive. A propulsion system consists of a source of mechanical power, and a propulsor (means of converting this power into propulsive force).

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