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This lecture covers the aims of monitoring atmospheric trace compounds, measurement strategies, design of monitoring stations, and the use of atmospheric measurements for interpretation. It discusses the historic development of air pollution, measurement practices, and quality assurance. The lecture also explores different measurement strategies, including in-situ and remote sensing methods, as well as the introduction to measuring trace gases in the atmosphere through regional, global networks, and emission measurements. It delves into the Swiss Network for Air Pollution Monitoring (NABEL) and the quality assurance processes involved in air pollution monitoring.