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This lecture by the instructor covers the application of machine learning techniques in quantum science and quantum computing, focusing on the challenges and advancements in understanding quantum many-body systems. The lecture delves into the mathematical foundations of quantum physics, the variational formulation as a solution approach, and the use of neural-network quantum states. It also explores the ground-state search problem, variational sampling methods, and the concept of variational quantum eigensolvers. The lecture concludes with an overview of the NetKet project, a machine learning toolkit for many-body quantum systems, and discusses the complexities and challenges in learning quantum states, especially in fermionic systems.