Lectures related to Inhibitor Design & Analysis

Enzymes: Catalytic Strategies

Explores enzyme catalytic strategies, including proteases and carbonic anhydrase, inhibition mechanisms, and specificity of serine proteases.

Chemical Biology meets Drug Discovery

Explores Chemical Biology, Drug Discovery, enzyme kinetics, and inhibition methods, including competitive and non-competitive inhibition.

Inclusion of Fermented Foods in Food Guides

Discusses the inclusion of fermented foods in global food guides, exploring their benefits and risks, enzyme kinetics, and the history of food enzymes.

Enzymes: Basic Concepts and Kinetics

Delves into enzymes' basic concepts, kinetics, and catalytic strategies for reaction acceleration.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.

Enzymes: Catalytic Strategies

Explores enzymes' catalytic strategies, including proteases and carbonic anhydrase, specificity, and pH influence on catalysis.

Activity-based Protein Profiling: Druggable Sites Identification

Explores Activity-based Protein Profiling for druggable site identification and strategies to minimize off-target reactivity of covalent inhibitors.

Enzymes: Basic Concepts and Kinetics

Explores enzymes' catalytic strategies, kinetics, and inhibition, emphasizing their role in accelerating biochemical reactions.

Protein-Ligand Interactions: Importance and Affinity

Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.

Enzymology: Structure, Kinetics, and Inhibition

Covers enzyme structure, kinetics, inhibition, specificity, and practical applications in enzymology.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Enzyme Kinetics: Affinity, Efficiency, and Inhibition

Explores enzyme-substrate affinity, catalytic efficiency, and various types of enzyme inhibition.

Chemical Kinetics: Reactions and Catalysis

Explores chemical kinetics, enzyme catalysis, and factors affecting reaction rates in biological systems.

Enzymatic Catalysis: Carbonic Anhydrase

Explores enzymatic catalysis using carbonic anhydrase as an example, covering inhibition types and physiological roles.

Enzymatic Catalysis & Inhibition

Explores enzymatic catalysis mechanisms and inhibition dynamics in catalysis and polymerization.

Enzyme Inhibition Mechanisms Log in to Mediaspace to watch this video

Explores enzyme activity modulation and small-molecule drug mechanisms, focusing on reversible and irreversible inhibition, progress curves, and covalent bond formation.

Inhibitor Design & Analysis Log in to Mediaspace to watch this video

Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.

Chemical Biology Fundamentals Log in to Mediaspace to watch this video

Covers the basics of Chemical Biology, focusing on enzyme inhibitors, metabolic regulation, and the interdisciplinary nature of the field.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.