Mediaspace scheduled maintenance: Aug 25, 2026 07:00 - 12:00 AM. During this time, videos will be temporarily unavailable. Check status updates.

Lecture

Cancer Immunotherapy: Concepts & Drug Delivery

Description

This lecture covers the fundamentals of cancer immunotherapy, focusing on the immune system's role in cancer and the development of immunosuppression mechanisms. It also delves into the history, mechanisms, and recent advancements in cancer immunotherapy. Additionally, the concept of drug delivery for cancer treatment is discussed, highlighting the challenges faced and the use of nanoparticles and polymers to enhance drug efficacy and reduce side effects.

Official source

Ontological neighbourhood

Health sciences

Immunology: Immune system

Biology

Cell biology: Cancer

Related concepts (32)

Cancer immunotherapy

Cancer immunotherapy (sometimes called immuno-oncology) is the stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the disease. It is an application of the fundamental research of cancer immunology and a growing subspecialty of oncology. Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them.

Cancer research

Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy.

Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient. The cells may have originated from the patient or from another individual. The cells are most commonly derived from the immune system with the goal of improving immune functionality and characteristics. In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. Comparatively, allogeneic therapies involve cells isolated and expanded from a donor separate from the patient receiving the cells.

Antigen-presenting cell

An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen bound by major histocompatibility complex (MHC) proteins on its surface; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T-cells. Almost all cell types can present antigens in some way. They are found in a variety of tissue types.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Related lectures (31)

Immune Cell Engineering: Targeting Checkpoint Inhibitors

Explores immune cell engineering for cancer therapy, emphasizing checkpoint inhibitor targeting through innovative delivery methods.

Design of Immunogenic Vaccines

Explores the challenges and triumphs in designing immunogenic vaccines, focusing on antigens, adjuvants, and the delivery strategies for effective vaccination.

Cancer Immunotherapies: History, Players, and Mechanisms

Explores the history, mechanisms, and players of cancer immunotherapies, including immune evasion strategies and the role of MHC in antigen presentation.

Immunoediting of Tumors: Experimental Evidence and Mechanisms

Explores tumor immunoediting, mechanisms of tumor escape, and cancer immunotherapy, emphasizing immune response regulation and recent drug approvals.

Material Engineering in Cancer Immunotherapy