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This lecture explores the evolution of Bio Molecular NanoComputing, starting from the limits of conventional lithography to the potential of using enzymes and cells for computational purposes. The presentation covers the development of new materials for memory improvement, the visibility of more than Moore technologies, and the challenges and advantages of using enzymes and cells for computing. It delves into the principles of molecular biology, the structure of DNA nucleotides, and the process of DNA replication. The lecture also discusses the application of enzyme-based logic systems, the interaction between antigens and antibodies, and the different types of ELISA techniques.