CRISPRCRISPR (ˈkrɪspər) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. These sequences are derived from DNA fragments of bacteriophages that had previously infected the prokaryote. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections. Hence these sequences play a key role in the antiviral (i.e. anti-phage) defense system of prokaryotes and provide a form of acquired immunity.
Bifurcation theoryBifurcation theory is the mathematical study of changes in the qualitative or topological structure of a given family of curves, such as the integral curves of a family of vector fields, and the solutions of a family of differential equations. Most commonly applied to the mathematical study of dynamical systems, a bifurcation occurs when a small smooth change made to the parameter values (the bifurcation parameters) of a system causes a sudden 'qualitative' or topological change in its behavior.
International System of UnitsThe International System of Units, internationally known by the abbreviation SI (for Système International), is the modern form of the metric system and the world's most widely used system of measurement. Established and maintained by the General Conference on Weights and Measures (CGPM), it is the only system of measurement with an official status in nearly every country in the world, employed in science, technology, industry, and everyday commerce.
Cas9Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna.
GeneIn biology, the word gene (from γένος, génos; meaning generation or birth or gender) can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function.
Bifurcation diagramIn mathematics, particularly in dynamical systems, a bifurcation diagram shows the values visited or approached asymptotically (fixed points, periodic orbits, or chaotic attractors) of a system as a function of a bifurcation parameter in the system. It is usual to represent stable values with a solid line and unstable values with a dotted line, although often the unstable points are omitted. Bifurcation diagrams enable the visualization of bifurcation theory.
Lefschetz fixed-point theoremIn mathematics, the Lefschetz fixed-point theorem is a formula that counts the fixed points of a continuous mapping from a compact topological space to itself by means of traces of the induced mappings on the homology groups of . It is named after Solomon Lefschetz, who first stated it in 1926. The counting is subject to an imputed multiplicity at a fixed point called the fixed-point index. A weak version of the theorem is enough to show that a mapping without any fixed point must have rather special topological properties (like a rotation of a circle).
MKS system of unitsThe MKS system of units is a physical system of measurement that uses the metre, kilogram, and second (MKS) as base units. The modern International System of Units (SI) was originally created as a formalization of the MKS system, and although the SI has been redefined several times since then and is now based entirely on fundamental physical constants, it still closely approximates the original MKS system for most practical purposes. By the mid-19th century, there was a demand by scientists to define a coherent system of units.
Imperial unitsThe imperial system of units, imperial system or imperial units (also known as British Imperial or Exchequer Standards of 1826) is the system of units first defined in the British Weights and Measures Act 1824 and continued to be developed through a series of Weights and Measures Acts and amendments. The imperial system developed from earlier English units as did the related but differing system of customary units of the United States. The imperial units replaced the Winchester Standards, which were in effect from 1588 to 1825.
SimilitudeSimilitude is a concept applicable to the testing of engineering models. A model is said to have similitude with the real application if the two share geometric similarity, kinematic similarity and dynamic similarity. Similarity and similitude are interchangeable in this context. The term dynamic similitude is often used as a catch-all because it implies that geometric and kinematic similitude have already been met. Similitude's main application is in hydraulic and aerospace engineering to test fluid flow conditions with scaled models.
