Lecture

Organic Chemistry: Reactive Intermediates and Their Stabilization

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In course

CH-120: Advanced general chemistry II

Acquisition des notions fondamentales liées à la réactivité des molécules organiques, identification de la structure de petites molécules organiques au moyen des techniques de spectrométrie de masse, spectroscopie infra-rouge et résonance magnétique nucléa ...

Description

This lecture covers the importance of organic chemistry, focusing on reactive intermediates and their stabilization mechanisms. It begins with a discussion on poisonous compounds found in snowdrops, such as galantamine and lycorine, which can cause severe health issues. The instructor explains how galantamine is used in treating Alzheimer's disease by inhibiting acetylcholinesterase, thus increasing acetylcholine levels. The lecture then transitions to the concept of reactive intermediates, including cations, radicals, and anions, and their stability based on the number of carbon substitutions. The instructor elaborates on the stabilization of these intermediates through inductive effects and resonance structures, emphasizing the role of orbital interactions. The discussion includes the significance of hyperconjugation and the influence of neighboring groups on the stability of carbocations and radicals. The lecture concludes with a summary of the principles of green chemistry and the importance of understanding these concepts for future applications in organic reactions.

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Instructors (2)

Luc Patiny

Expertise Cheminformatics, Data management, Data processing, Javascript developmentLast updated on April 16, 2023. Teaching & PhD Courses Advanced general chemistry II CH-120 Fundamental knowledge on the reactivity of organic compounds and their identification by mass spectrometry, IR spectroscopy and nuclear magnetic resonance. Basic and advanced NMR - Level 1 A (EPFL) CH-601(x) Basic theoretical and experimental aspects of NMR will be taught. Students will be familarized w

Jérôme Waser

Jérôme Waser biography and CV's are available on the following website: http://lcso.epfl.ch/waser

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