Protein domainIn molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions.
UltrahydrophobicityIn chemistry and materials science, ultrahydrophobic (or superhydrophobic) surfaces are highly hydrophobic, i.e., extremely difficult to wet. The contact angles of a water droplet on an ultrahydrophobic material exceed 150°. This is also referred to as the lotus effect, after the superhydrophobic leaves of the lotus plant. A droplet striking these kinds of surfaces can fully rebound like an elastic ball. Interactions of bouncing drops can be further reduced using special superhydrophobic surfaces that promote symmetry breaking, pancake bouncing or waterbowl bouncing.
HydrophobeIn chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe). In contrast, hydrophiles are attracted to water. Hydrophobic molecules tend to be nonpolar and, thus, prefer other neutral molecules and nonpolar solvents. Because water molecules are polar, hydrophobes do not dissolve well among them. Hydrophobic molecules in water often cluster together, forming micelles. Water on hydrophobic surfaces will exhibit a high contact angle.
Folding@homeFolding@home (FAH or F@h) is a distributed computing project aimed to help scientists develop new therapeutics for a variety of diseases by the means of simulating protein dynamics. This includes the process of protein folding and the movements of proteins, and is reliant on simulations run on volunteers' personal computers. Folding@home is currently based at the University of Pennsylvania and led by Greg Bowman, a former student of Vijay Pande.
Protein tertiary structureProtein tertiary structure is the three dimensional shape of a protein. The tertiary structure will have a single polypeptide chain "backbone" with one or more protein secondary structures, the protein domains. Amino acid side chains may interact and bond in a number of ways. The interactions and bonds of side chains within a particular protein determine its tertiary structure. The protein tertiary structure is defined by its atomic coordinates. These coordinates may refer either to a protein domain or to the entire tertiary structure.
Protein fold classIn molecular biology, protein fold classes are broad categories of protein tertiary structure topology. They describe groups of proteins that share similar amino acid and secondary structure proportions. Each class contains multiple, independent protein superfamilies (i.e. are not necessarily evolutionarily related to one another). Four large classes of protein that are generally agreed upon by the two main structure classification databases (SCOP and CATH).
WettingWetting is the ability of a liquid to maintain contact with a solid surface, resulting from intermolecular interactions when the two are brought together. This happens in presence of a gaseous phase or another liquid phase not miscible with the first one. The degree of wetting (wettability) is determined by a force balance between adhesive and cohesive forces. Wetting is important in the bonding or adherence of two materials. Wetting and the surface forces that control wetting are also responsible for other related effects, including capillary effects.
Instructions per secondInstructions per second (IPS) is a measure of a computer's processor speed. For complex instruction set computers (CISCs), different instructions take different amounts of time, so the value measured depends on the instruction mix; even for comparing processors in the same family the IPS measurement can be problematic. Many reported IPS values have represented "peak" execution rates on artificial instruction sequences with few branches and no cache contention, whereas realistic workloads typically lead to significantly lower IPS values.
Instructions per cycleIn computer architecture, instructions per cycle (IPC), commonly called instructions per clock is one aspect of a processor's performance: the average number of instructions executed for each clock cycle. It is the multiplicative inverse of cycles per instruction. While early generations of CPUs carried out all the steps to execute an instruction sequentially, modern CPUs can do many things in parallel.
Instruction set architectureIn computer science, an instruction set architecture (ISA), also called computer architecture, is an abstract model of a computer. A device that executes instructions described by that ISA, such as a central processing unit (CPU), is called an implementation. In general, an ISA defines the supported instructions, data types, registers, the hardware support for managing main memory, fundamental features (such as the memory consistency, addressing modes, virtual memory), and the input/output model of a family of implementations of the ISA.
Complex instruction set computerA complex instruction set computer (CISC ˈsɪsk) is a computer architecture in which single instructions can execute several low-level operations (such as a load from memory, an arithmetic operation, and a memory store) or are capable of multi-step operations or addressing modes within single instructions. The term was retroactively coined in contrast to reduced instruction set computer (RISC) and has therefore become something of an umbrella term for everything that is not RISC, where the typical differentiating characteristic is that most RISC designs use uniform instruction length for almost all instructions, and employ strictly separate load and store instructions.
Instruction pipeliningIn computer engineering, instruction pipelining is a technique for implementing instruction-level parallelism within a single processor. Pipelining attempts to keep every part of the processor busy with some instruction by dividing incoming instructions into a series of sequential steps (the eponymous "pipeline") performed by different processor units with different parts of instructions processed in parallel. In a pipelined computer, instructions flow through the central processing unit (CPU) in stages.
HydrophileA hydrophile is a molecule or other molecular entity that is attracted to water molecules and tends to be dissolved by water. In contrast, hydrophobes are not attracted to water and may seem to be repelled by it. Hygroscopics are attracted to water, but are not dissolved by water. A hydrophilic molecule or portion of a molecule is one whose interactions with water and other polar substances are more thermodynamically favorable than their interactions with oil or other hydrophobic solvents.
Cycles per instructionIn computer architecture, cycles per instruction (aka clock cycles per instruction, clocks per instruction, or CPI) is one aspect of a processor's performance: the average number of clock cycles per instruction for a program or program fragment. It is the multiplicative inverse of instructions per cycle. The average of Cycles Per Instruction in a given process (CPI) is defined by the following weighted average: Where is the number of instructions for a given instruction type , is the clock-cycles for that instruction type and is the total instruction count.
Reduced instruction set computerIn computer engineering, a reduced instruction set computer (RISC) is a computer architecture designed to simplify the individual instructions given to the computer to accomplish tasks. Compared to the instructions given to a complex instruction set computer (CISC), a RISC computer might require more instructions (more code) in order to accomplish a task because the individual instructions are written in simpler code.
Compressed instruction setA compressed instruction set, or simply compressed instructions, are a variation on a microprocessor's instruction set architecture (ISA) that allows instructions to be represented in a more compact format. In most real-world examples, compressed instructions are 16 bits long in a processor that would otherwise use 32-bit instructions. The 16-bit ISA is a subset of the full 32-bit ISA, not a separate instruction set. The smaller format requires some tradeoffs: generally, there are fewer instructions available, and fewer processor registers can be used.
Polar ice capA polar ice cap or polar cap is a high-latitude region of a planet, dwarf planet, or natural satellite that is covered in ice. There are no requirements with respect to size or composition for a body of ice to be termed a polar ice cap, nor any geological requirement for it to be over land, but only that it must be a body of solid phase matter in the polar region. This causes the term "polar ice cap" to be something of a misnomer, as the term ice cap itself is applied more narrowly to bodies that are over land, and cover less than 50,000 km2: larger bodies are referred to as ice sheets.
SequenceIn mathematics, a sequence is an enumerated collection of objects in which repetitions are allowed and order matters. Like a set, it contains members (also called elements, or terms). The number of elements (possibly infinite) is called the length of the sequence. Unlike a set, the same elements can appear multiple times at different positions in a sequence, and unlike a set, the order does matter. Formally, a sequence can be defined as a function from natural numbers (the positions of elements in the sequence) to the elements at each position.
Messenger RNAIn molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the process of transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence.
Polar bearThe polar bear (Ursus maritimus) is a large bear native to the Arctic and surrounding areas. It is closely related to the brown bear, and the two species can interbreed. The polar bear is the largest extant species of bear and land carnivore, with adult males weighing . The species is sexually dimorphic, as adult females are much smaller. The polar bear is white- or yellowish-furred with black skin and a thick layer of fat. It is more slender than the brown bear, with a narrower skull, longer neck and lower shoulder hump.
