Lecture

Na Transport: Ussing's Model

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In courses (2)

BIO-378: Physiology lab I

Le TP de physiologie introduit les approches expérimentales du domaine biomédical, avec les montages de mesure, les capteurs, le conditionnement des signaux, l'acquisition et traitement de données. Les résultats physiologiques finaux illustrent le contenu ...

BIO-379: Physiology lab II

Description

This lecture covers the principles of epithelial transport, focusing on Ussing's model and the measurement of trans-epithelial potential and current. It discusses the components of the model, such as Na channels, NaKATPase, and tight junctions, and the experimental set-up for investigating them.

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Instructor

André Pexieder

Teaching & PhD Courses Physiology lab I BIO-378 The physiology laboratory introduce the experimental methods in the biomedical field, including experimental set-ups, transducers, signal conditioning, data acquisition and processing.The physiological end results illustrate the contents of the Physiologie par systèmes course. Physiology lab II BIO-379 The physiology laboratory introduce the experimental methods in the biomedical field, including experimental set-ups, transducer

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Related concepts (31)

Active transport

In cellular biology, active transport is the movement of molecules or ions across a cell membrane from a region of lower concentration to a region of higher concentration—against the concentration gradient. Active transport requires cellular energy to achieve this movement. There are two types of active transport: primary active transport that uses adenosine triphosphate (ATP), and secondary active transport that uses an electrochemical gradient.

Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters.

Membrane transport protein

A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembrane proteins; that is they exist permanently within and span the membrane across which they transport substances. The proteins may assist in the movement of substances by facilitated diffusion or active transport.

Voltage clamp

The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level. A basic voltage clamp will iteratively measure the membrane potential, and then change the membrane potential (voltage) to a desired value by adding the necessary current. This "clamps" the cell membrane at a desired constant voltage, allowing the voltage clamp to record what currents are delivered.

Sodium–potassium pump

The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na+/K+-ATPase, Na+/K+ pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na+/K+-ATPase enzyme is active (i.e. it uses energy from ATP). For every ATP molecule that the pump uses, three sodium ions are exported and two potassium ions are imported. Thus, there is a net export of a single positive charge per pump cycle.

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Ion Channels: Structure and Function

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Ion Channels MOOC: Simulation Neurocience

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Related concepts (31)

Active transport

Ion channel

Membrane transport protein

Voltage clamp

Sodium–potassium pump