Lectures related to Frontiers in Chemical Biology

Protein Induced Degradation: Druggability Strategy

Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.

Quantitative Proteome Profiling: Chemical Target Identification

Explores quantitative proteome profiling for drug target identification through activity-based protein profiling and advanced mass spectrometry techniques.

Designing Targeted Protein Degraders

Explores the design and validation of targeted protein degraders, including PROTACs and molecular glue compounds, emphasizing the importance of proper analyses and validations in TPD research.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

The ClpXP Proteolytic Complex: Basic Principles to Drug Discovery

Explores the ClpXP proteolytic complex, its drug targeting potential, and antimicrobial applications through compound screening.

PROTACs: Catalytic Protein Knockdown Strategy

Explores PROTACs, a catalytic protein knockdown strategy with potential in tumor treatment and drug development.

Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.

DNA-Encoded Libraries

Explores DNA-encoded libraries for drug discovery, covering synthesis techniques, pros and cons, and diverse DEL methods.

Drug Target Discovery: Thermal Shift Profiling

Covers drug target discovery through stability shifts and proteomics with isobaric tags.

Kidney-on-a-Chip Technologies

Covers the state-of-the-art kidney-on-chip technologies aiming to facilitate pharmaceutical research and eliminate animal testing.

Protein Modifications: Ubiquitination and Acylation

Explores protein modifications through ubiquitination, acylation, and Ras acylation importance.

Protein Function Regulation: Degradation Mechanisms

Covers the mechanisms of protein degradation, including the roles of the proteasome and autophagy in regulating protein function.

Enzyme Drug Targets

Explores enzyme drug targets, tyrosine kinase inhibitors, vascular tone control, and viral life cycle interventions.

Deep Generative Models in Drug Discovery

Explores the application of deep generative models in drug discovery, focusing on designing small molecules and optimizing molecular structures.

Proteomics Profiling Methods

Explores proteomics profiling methods, including ABPP, MS approaches, and quantitative target identification using SILAC and TMT labeling.

Proteome Mapping & Electrophile Responsivity

Explores proteome mapping, electrophile responsivity, precision medicine, and spatial omics technologies in drug target identification.

Protein Profiling: Mass Spectrometry and Target-ID Tools

Explores protein profiling using mass spectrometry, target enrichment techniques, and quantitative proteomics.

Protein-Protein Interaction Networks

Explores protein-protein interaction networks, binding importance, experimental approaches, drug target identification, and network construction.

Interrogating SAR: Medicinal Chemistry Log in to Mediaspace to watch this video

Covers medicinal chemistry basics, high-throughput screening, lead discovery milestones, and compound selectivity in drug optimization.

Enzyme Inhibition Mechanisms Log in to Mediaspace to watch this video

Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.