Lecture

Rules of Development

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Description

This lecture explores the rules and pillars of development, focusing on cell-autonomous processes, extrinsic regulation, and interactions between cells. It delves into how signals and morphogens play a crucial role in determining cell fate and differentiation, emphasizing the spatiotemporal nature of developmental cues.

This video is available exclusively on Mediaspace for a restricted audience. Please log in to MediaSpace to access it if you have the necessary permissions.

Watch on Mediaspace

Official source

Ontological neighbourhood

Biology

Cell biology: Cell signaling

Genetics: Molecular genetics

Related concepts (32)

Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA.

Regulation of gene expression

Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from transcriptional initiation, to RNA processing, and to the post-translational modification of a protein.

Cell fate determination

Within the field of developmental biology, one goal is to understand how a particular cell develops into a final cell type, known as fate determination. Within an embryo, several processes play out at the cellular and tissue level to create an organism. These processes include cell proliferation, differentiation, cellular movement and programmed cell death. Each cell in an embryo receives molecular signals from neighboring cells in the form of proteins, RNAs and even surface interactions.

Neural crest

Neural crest cells are a temporary group of cells that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia. After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. During neurulation, the borders of the neural plate, also known as the neural folds, converge at the dorsal midline to form the neural tube.

Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism.

Related lectures (64)

Gene Regulatory Networks MOOC: Neuroscience Reconstructed: Genetics and Brain Development

Explores how gene regulatory networks encode changes in cell development and the importance of interactions between different regulatory networks.

Eukaryotic Transcription: Initiation and Elongation

Explores eukaryotic transcription initiation, elongation, and gene regulation complexity.

Embryonic Induction: Gastrulation and Patterning

Explores embryonic induction, gastrulation, germ layer patterning, and signal transduction pathways in development.

Embryonic Induction: Spemann and Mangold

Explores embryonic induction through Spemann and Mangold's experiments, highlighting organizer roles, neural plate formation, and Activin as a morphogen.

Single-cell and Spatially Resolved RNA-seq MOOC: Neuroscience Reconstructed: Genetics and Brain Development