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This lecture by the instructor covers the principles and tools of BioNanoArchitectonics, starting with the basics of Particle Physics and Quantum Mechanics, moving on to the development of self-assembled molecular networks and modular approaches to 2D networks on surfaces. The lecture explores the use of Nature's design in functional materials, focusing on catalysis and biomedical applications. It delves into the vision of artificial leaf technology and the study of surface evolution using electrochemical scanning tunneling microscopy. The presentation concludes with discussions on smart responsive materials, reversible host-guest systems, and the control of molecules at the nanoscale.