Statistical classificationIn statistics, classification is the problem of identifying which of a set of categories (sub-populations) an observation (or observations) belongs to. Examples are assigning a given email to the "spam" or "non-spam" class, and assigning a diagnosis to a given patient based on observed characteristics of the patient (sex, blood pressure, presence or absence of certain symptoms, etc.). Often, the individual observations are analyzed into a set of quantifiable properties, known variously as explanatory variables or features.
Logistic regressionIn statistics, the logistic model (or logit model) is a statistical model that models the probability of an event taking place by having the log-odds for the event be a linear combination of one or more independent variables. In regression analysis, logistic regression (or logit regression) is estimating the parameters of a logistic model (the coefficients in the linear combination).
Protein function predictionProtein function prediction methods are techniques that bioinformatics researchers use to assign biological or biochemical roles to proteins. These proteins are usually ones that are poorly studied or predicted based on genomic sequence data. These predictions are often driven by data-intensive computational procedures. Information may come from nucleic acid sequence homology, gene expression profiles, protein domain structures, text mining of publications, phylogenetic profiles, phenotypic profiles, and protein-protein interaction.
Multinomial logistic regressionIn statistics, multinomial logistic regression is a classification method that generalizes logistic regression to multiclass problems, i.e. with more than two possible discrete outcomes. That is, it is a model that is used to predict the probabilities of the different possible outcomes of a categorically distributed dependent variable, given a set of independent variables (which may be real-valued, binary-valued, categorical-valued, etc.).
Multiclass classificationIn machine learning and statistical classification, multiclass classification or multinomial classification is the problem of classifying instances into one of three or more classes (classifying instances into one of two classes is called binary classification). While many classification algorithms (notably multinomial logistic regression) naturally permit the use of more than two classes, some are by nature binary algorithms; these can, however, be turned into multinomial classifiers by a variety of strategies.
Adjacency matrixIn graph theory and computer science, an adjacency matrix is a square matrix used to represent a finite graph. The elements of the matrix indicate whether pairs of vertices are adjacent or not in the graph. In the special case of a finite simple graph, the adjacency matrix is a (0,1)-matrix with zeros on its diagonal. If the graph is undirected (i.e. all of its edges are bidirectional), the adjacency matrix is symmetric. The relationship between a graph and the eigenvalues and eigenvectors of its adjacency matrix is studied in spectral graph theory.
Linear regressionIn statistics, linear regression is a linear approach for modelling the relationship between a scalar response and one or more explanatory variables (also known as dependent and independent variables). The case of one explanatory variable is called simple linear regression; for more than one, the process is called multiple linear regression. This term is distinct from multivariate linear regression, where multiple correlated dependent variables are predicted, rather than a single scalar variable.
Protein structure predictionProtein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its secondary and tertiary structure from primary structure. Structure prediction is different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by computational biology; and it is important in medicine (for example, in drug design) and biotechnology (for example, in the design of novel enzymes).
Protein–protein interaction predictionProtein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions between pairs or groups of proteins. Understanding protein–protein interactions is important for the investigation of intracellular signaling pathways, modelling of protein complex structures and for gaining insights into various biochemical processes.
Adjacency listIn graph theory and computer science, an adjacency list is a collection of unordered lists used to represent a finite graph. Each unordered list within an adjacency list describes the set of neighbors of a particular vertex in the graph. This is one of several commonly used representations of graphs for use in computer programs. An adjacency list representation for a graph associates each vertex in the graph with the collection of its neighbouring vertices or edges.
Laplacian matrixIn the mathematical field of graph theory, the Laplacian matrix, also called the graph Laplacian, admittance matrix, Kirchhoff matrix or discrete Laplacian, is a matrix representation of a graph. Named after Pierre-Simon Laplace, the graph Laplacian matrix can be viewed as a matrix form of the negative discrete Laplace operator on a graph approximating the negative continuous Laplacian obtained by the finite difference method. The Laplacian matrix relates to many useful properties of a graph.
Incidence matrixIn mathematics, an incidence matrix is a logical matrix that shows the relationship between two classes of objects, usually called an incidence relation. If the first class is X and the second is Y, the matrix has one row for each element of X and one column for each element of Y. The entry in row x and column y is 1 if x and y are related (called incident in this context) and 0 if they are not. There are variations; see below. Incidence matrix is a common graph representation in graph theory.
Probabilistic classificationIn machine learning, a probabilistic classifier is a classifier that is able to predict, given an observation of an input, a probability distribution over a set of classes, rather than only outputting the most likely class that the observation should belong to. Probabilistic classifiers provide classification that can be useful in its own right or when combining classifiers into ensembles. Formally, an "ordinary" classifier is some rule, or function, that assigns to a sample x a class label ŷ: The samples come from some set X (e.
Matrix additionIn mathematics, matrix addition is the operation of adding two matrices by adding the corresponding entries together. For a vector, , adding two matrices would have the geometric effect of applying each matrix transformation separately onto , then adding the transformed vectors. However, there are other operations that could also be considered addition for matrices, such as the direct sum and the Kronecker sum. Two matrices must have an equal number of rows and columns to be added.
Logical matrixA logical matrix, binary matrix, relation matrix, Boolean matrix, or (0, 1)-matrix is a matrix with entries from the Boolean domain B = {0, 1}. Such a matrix can be used to represent a binary relation between a pair of finite sets. It is an important tool in combinatorial mathematics and theoretical computer science.
Ordered logitIn statistics, the ordered logit model (also ordered logistic regression or proportional odds model) is an ordinal regression model—that is, a regression model for ordinal dependent variables—first considered by Peter McCullagh. For example, if one question on a survey is to be answered by a choice among "poor", "fair", "good", "very good" and "excellent", and the purpose of the analysis is to see how well that response can be predicted by the responses to other questions, some of which may be quantitative, then ordered logistic regression may be used.
Causal inferenceCausal inference is the process of determining the independent, actual effect of a particular phenomenon that is a component of a larger system. The main difference between causal inference and inference of association is that causal inference analyzes the response of an effect variable when a cause of the effect variable is changed. The science of why things occur is called etiology, and can be described using the language of scientific causal notation. Causal inference is said to provide the evidence of causality theorized by causal reasoning.
Logistic distributionIn probability theory and statistics, the logistic distribution is a continuous probability distribution. Its cumulative distribution function is the logistic function, which appears in logistic regression and feedforward neural networks. It resembles the normal distribution in shape but has heavier tails (higher kurtosis). The logistic distribution is a special case of the Tukey lambda distribution.
Electromagnetic interferenceElectromagnetic interference (EMI), also called radio-frequency interference (RFI) when in the radio frequency spectrum, is a disturbance generated by an external source that affects an electrical circuit by electromagnetic induction, electrostatic coupling, or conduction. The disturbance may degrade the performance of the circuit or even stop it from functioning. In the case of a data path, these effects can range from an increase in error rate to a total loss of the data.
Binary classificationBinary classification is the task of classifying the elements of a set into two groups (each called class) on the basis of a classification rule. Typical binary classification problems include: Medical testing to determine if a patient has certain disease or not; Quality control in industry, deciding whether a specification has been met; In information retrieval, deciding whether a page should be in the result set of a search or not. Binary classification is dichotomization applied to a practical situation.
