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Lecture

Biofabrication and Bioprinting

Description

This lecture covers the concepts of biofabrication and bioprinting, including the automated generation of biologically functional products from living cells, bioactive molecules, and biomaterials. It explains the building blocks in biofabrication, various bioprinting technologies like inkjet printing and extrusion, and the challenges and advancements in creating complex structures. The lecture also delves into the use of sacrificial materials, viscosity enhancers, and multimaterial printing for creating intricate tissue constructs. Furthermore, it discusses in vivo and in situ printing, hybrid printing with dECM-derived bioinks, and the future prospects of bioprinting as a clinically-ready technology.

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Related concepts (32)

3D printing

3D printing or additive manufacturing is the construction of a three-dimensional object from a CAD model or a digital 3D model. It can be done in a variety of processes in which material is deposited, joined or solidified under computer control, with material being added together (such as plastics, liquids or powder grains being fused), typically layer by layer. In the 1980s, 3D printing techniques were considered suitable only for the production of functional or aesthetic prototypes, and a more appropriate term for it at the time was rapid prototyping.

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Digital printing

Digital printing is a method of printing from a digital-based image directly to a variety of media. It usually refers to professional printing where small-run jobs from desktop publishing and other digital sources are printed using large-format and/or high-volume laser or inkjet printers. Digital printing has a higher cost per page than more traditional offset printing methods, but this price is usually offset by avoiding the cost of all the technical steps required to make printing plates.

Inkjet printing

Inkjet printing is a type of computer printing that recreates a by propelling droplets of ink onto paper and plastic substrates. Inkjet printers were the most commonly used type of printer in 2008, and range from small inexpensive consumer models to expensive professional machines. By 2019, laser printers outsold inkjet printers by nearly a 2:1 ratio, 9.6% vs 5.1% of all computer peripherals.As of 2023, sublimation printers have outsold inkjet printers by nearly a 2:1 ratio, accounting for 9.

Linear complex structure

In mathematics, a complex structure on a real vector space V is an automorphism of V that squares to the minus identity, −I. Such a structure on V allows one to define multiplication by complex scalars in a canonical fashion so as to regard V as a complex vector space. Every complex vector space can be equipped with a compatible complex structure, however, there is in general no canonical such structure. Complex structures have applications in representation theory as well as in complex geometry where they play an essential role in the definition of almost complex manifolds, by contrast to complex manifolds.

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