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This lecture explores the methodologies and approaches to studying the Human Visual System (HVS), including neurophysics, psychophysics, and engineering modeling. It delves into the anatomy of the HVS, color perception by the brain, and the spectral and sensitivity properties of the human eye. The lecture also covers the structure and processing in the retina, the role of cones and rods in vision, and the complex signal processing in the visual cortex. Furthermore, it discusses the focus of attention models and their integration into objective quality metrics, emphasizing the importance of salience and relevance in visual processing.