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Lecture

Organometallic Reactions Overview

In course

CH-422: Catalyst design for synthesis

This course on homogeneous catalysis provide a detailed understanding of how these catalysts work at a mechanistic level and give examples of catalyst design for important reactions (hydrogenation, olefin metathesis, cross-coupling). ...

Description

This lecture provides a comprehensive overview of organometallic reactions, including ligand association and dissociation, oxidative addition, reductive elimination, migratory insertion, and B-elimination. It also covers the synthesis of carbene complexes, metathesis in synthesis, and ring opening metathesis polymerization.

Instructor

Xile Hu

Xile Hu was born in 1978 in Putian, southeastern China. He entered the Peking University in Beijing in 1996. Besides learning too little chemistry, his biggest regret in the college was not able to correct his southern accent in Mandarin. After graduated from PKU, he went to the United States and began his doctoral studies at the University of California, San Diego. In December 2004, he finished with a Ph.D. in chemistry and some fond memories of the beautiful city of San Diego. He then moved to the Los Angeles area and become a postdoctoral scholar at the California Institute of Technology. There he enjoyed numerous stimulating scientific (and other) discussions with friends and colleagues. He also made plenty of friends outside the campus and was a frequent in many local Chinese restaurants. In 2007, after two pleasant visits to Switzerland, he decided to move across the continent one more time and join the faculty of the École Polytechnique Fédérale de Lausanne (EPFL). He now directs the Laboratory of Inorganic Synthesis and Catalysis and is interested in developing chemistry for synthesis, energy and sustainability.

Official source

Ontological neighbourhood

Chemistry

Organic chemistry: Organometallic chemistry

Related concepts (32)

Olefin metathesis

Olefin metathesis is an organic reaction that entails the redistribution of fragments of alkenes (olefins) by the scission and regeneration of carbon-carbon double bonds. Because of the relative simplicity of olefin metathesis, it often creates fewer undesired by-products and hazardous wastes than alternative organic reactions. For their elucidation of the reaction mechanism and their discovery of a variety of highly active catalysts, Yves Chauvin, Robert H. Grubbs, and Richard R.

Transition metal carbene complex

A transition metal carbene complex is an organometallic compound featuring a divalent organic ligand. The divalent organic ligand coordinated to the metal center is called a carbene. Carbene complexes for almost all transition metals have been reported. Many methods for synthesizing them and reactions utilizing them have been reported. The term carbene ligand is a formalism since many are not derived from carbenes and almost none exhibit the reactivity characteristic of carbenes.

Ring-opening polymerization

In polymer chemistry, ring-opening polymerization (ROP) is a form of chain-growth polymerization, in which the terminus of a polymer chain attacks cyclic monomers to form a longer polymer (see figure). The reactive center can be radical, anionic or cationic. Some cyclic monomers such as norbornene or cyclooctadiene can be polymerized to high molecular weight polymers by using metal catalysts. ROP is a versatile method for the synthesis of biopolymers. Ring-opening of cyclic monomers is often driven by the relief of bond-angle strain.

Persistent carbene

A persistent carbene (also known as stable carbene) is a type of carbene demonstrating particular stability. The best-known examples and by far largest subgroup are the N-heterocyclic carbenes (NHC) (sometimes called Arduengo carbenes), for example diaminocarbenes with the general formula (R2N)2C:, where the four R moieties are typically alkyl and aryl groups. The groups can be linked to give heterocyclic carbenes, such as those derived from imidazole, imidazoline, thiazole or triazole.

Carbene

In organic chemistry, a carbene is a molecule containing a neutral carbon atom with a valence of two and two unshared valence electrons. The general formula is or where the R represents substituents or hydrogen atoms. The term "carbene" may also refer to the specific compound , also called methylene, the parent hydride from which all other carbene compounds are formally derived. Carbenes are classified as either singlets or triplets, depending upon their electronic structure.

Related lectures (31)

Homogeneous Catalysis Basics

Introduces the basics of homogeneous catalysis, focusing on reaction mechanisms and catalyst design.

Oxidative Addition and Reductive Elimination

Explores oxidative addition, reductive elimination, insertion reactions, and factors influencing these reactions in organometallic chemistry.

Organometallic Reactions

Covers main organometallic reactions and factors driving them, with exercises predicting reaction products.

Metal Carbonyls: Applications and Reactions

Discusses metal carbonyls and their applications in catalysis and chemical reactions, including the introduction of metal carbines and their significance in synthetic chemistry.

Phosphine Dissociation Mechanisms