Lecture

Consequences of T Cell Activation: Signaling Pathways and Regulation

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In course

BIO-310: Immunology

Ce cours décrit le fonctionnement du système immunitaire humain et les bases immunologiques de la vaccination, de la transplantation, de l'immunothérapie, et de l'allergie. Il présente aussi le rôle des cellules souches dans la formation des tissus, notamm ...

Description

This lecture covers the signaling pathways involved in T cell activation, from the initial steps of signal transduction to the activation of transcription factors and gene expression. It also discusses the consequences of T cell activation, including proliferation, differentiation, and interactions with other immune cells. The role of key molecules such as CD40 ligand and cytokines in regulating T cell responses is highlighted, along with the impact of immunosuppressants on T cell signaling. The lecture emphasizes the complex network of interactions that govern T cell behavior during an adaptive immune response.

In MOOC

Introduction to immunology (part 1)

Instructors (2)

Bruno Lemaitre

Personal Webpage http://brunolemaitre.ch Personal Webpage http://brunolemaitre.ch Teaching & PhD PhD Students Blandine Ribotta, Yao Tian, Désirée Popelka, Prince Kumar Sah, Siqi Wang, Kenan Krakovic, Nathan Alexandre Klotz Past EPFL PhD Students Sveta Chakrabarti, Olivier Binggeli, Jeremy Keith Herren, Juan Camilo Paredes Escobar, Alfred Chng, Maroun Bou Sleiman, Jan Paul Dudzic, Mario Gonzalo Garcia Arraez, Claudia Melcarne, Alice Marra, Bianca Marie Petrignani, Mark Austin Hanson, Alexia Laurie Carboni

David Michael Suter

Teaching & PhD PhD Students Ekaterina Lyublinskaya, Yuliia Romaniuk, Joanna Agnieszka Dembska, Solomon Nshemereirwe Past EPFL PhD Students Onur Tidin, Aleksandra Mandic, Daniel Strebinger, Andrea Brigitta Alber, Mahé Raccaud, Torgil Elias Friman, Shoujie Sun, Silja Michelle Placzek, Romane Mizeret, Benjamin Martin, Sim Sakong, Stella Katharina Krämer Past EPFL PhD Students as codirector Damien Lionel Nicolas, Isabelle Chareyron, Christopher Tadhg James Wall, Kolly Dominique Courses Immunology BI

Official source

Quiz

Ontological neighbourhood

Health sciences

Immunology: Immune system

Related concepts (32)

Immune response

An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. In addition, there are other forms of immune response.

Adaptive immune system

The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of specialized, systemic cells and processes that eliminate pathogens or prevent their growth. The acquired immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Like the innate system, the adaptive immune system includes both humoral immunity components and cell-mediated immunity components and destroys invading pathogens.

Immune system

The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinters, distinguishing them from the organism's own healthy tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli.

Innate immune system

The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an alternate defense strategy and is the dominant immune system response found in plants, fungi, insects, and primitive multicellular organisms (see Beyond vertebrates).

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

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