Lecture

Synaptic Plasticity: Mechanisms and Models

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Description

This lecture explores different forms of synaptic plasticity, including short-term and long-term enhancement, depression, and depletion. It delves into the mechanisms of synaptic plasticity, such as Hebbian learning rules and the role of NMDAR and AMPAR. Various experimental protocols for inducing plasticity are discussed, from low-frequency to high-frequency stimulation. The lecture also covers spike-time dependent plasticity and the involvement of dendritic spines in plasticity processes. Different computational models, including rate-based, spike-timing-based, voltage-based, calcium-based, and subcellular models, are presented to understand the complex dynamics of synaptic plasticity.

Official source

Ontological neighbourhood

Biology

Cell biology: Neurotransmission, Neuroplasticity

Related concepts (32)

Synaptic plasticity

In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see Hebbian theory). Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse.

Spike-timing-dependent plasticity

Spike-timing-dependent plasticity (STDP) is a biological process that adjusts the strength of connections between neurons in the brain. The process adjusts the connection strengths based on the relative timing of a particular neuron's output and input action potentials (or spikes). The STDP process partially explains the activity-dependent development of nervous systems, especially with regard to long-term potentiation and long-term depression.

Romani diaspora

The Romani people have several distinct populations, the largest being the Roma and the Calé, who reached Anatolia and the Balkans in the early 12th century, from a migration out of the Indian subcontinent beginning about 1st century – 2nd century AD. They settled in the areas of present-day Turkey, Greece, Serbia, Romania, Croatia, Moldova, Bulgaria, North Macedonia, Hungary, Albania, Kosovo, Bosnia and Herzegovina, Czech Republic, Slovenia and Slovakia, by order of volume, and Spain.

Hebbian theory

Hebbian theory is a neuropsychological theory claiming that an increase in synaptic efficacy arises from a presynaptic cell's repeated and persistent stimulation of a postsynaptic cell. It is an attempt to explain synaptic plasticity, the adaptation of brain neurons during the learning process. It was introduced by Donald Hebb in his 1949 book The Organization of Behavior. The theory is also called Hebb's rule, Hebb's postulate, and cell assembly theory.

Romani society and culture

The Romani people are a distinct ethnic and cultural group of peoples living all across the globe, who share a family of languages and sometimes a traditional nomadic mode of life. Though their exact origins are unclear, central India is a notable point of origin. Their language shares a common origin with, and is similar to, modern-day Gujarati and Rajasthani, borrowing loan words from other languages as they migrated from India. In Europe, even though their culture has been victimized by other cultures, they have still found a way to maintain their heritage and society.

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