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This lecture commemorates the 50th anniversary of CECAM and the Berni J. Alder CECAM Prize awarded in 2019. It covers the history of CECAM, the European Research Council, and the collaboration between various institutions. The slides showcase milestones like the development of cellular automata supercomputers for fluid dynamics modeling and the lattice gas automata for the Navier-Stokes equation. The lecture delves into the lattice Boltzmann equation for quantum mechanics, slip motion at fluid-solid interfaces, and the mesoscopic modeling of catalytic microchannels. It also explores topics like entropic lattice Boltzmann, LB applications in graphene, and femto-hydrodynamics. The presentation concludes with acknowledgments to key figures and institutions in the field.