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This lecture covers the principles and applications of PET imaging, focusing on topics such as the history, energetics, metabolic rate, physical principles, tracers, detection, technical advancements, data correction, standardized uptake value, radiopharmaceuticals manufacture, PET applications, associated risks, and future perspectives. It discusses the use of PET in oncology, psychiatric diseases, and the manufacture of radiopharmaceuticals. The lecture also explores the significance of PET scans in diagnosing diseases, the process of image acquisition, and the future trends in PET imaging technology.