MicrofluidicsMicrofluidics refers to a system that manipulates a small amount of fluids ((10−9 to 10−18 liters) using small channels with sizes ten to hundreds micrometres. It is a multidisciplinary field that involves molecular analysis, biodefence, molecular biology, and microelectronics. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening.
Droplet-based microfluidicsDroplet-based microfluidics manipulate discrete volumes of fluids in immiscible phases with low Reynolds number and laminar flow regimes. Interest in droplet-based microfluidics systems has been growing substantially in past decades. Microdroplets offer the feasibility of handling miniature volumes (μl to fl) of fluids conveniently, provide better mixing, encapsulation, sorting, sensing and are suitable for high throughput experiments.
Merge sortIn computer science, merge sort (also commonly spelled as mergesort) is an efficient, general-purpose, and comparison-based sorting algorithm. Most implementations produce a stable sort, which means that the relative order of equal elements is the same in the input and output. Merge sort is a divide-and-conquer algorithm that was invented by John von Neumann in 1945. A detailed description and analysis of bottom-up merge sort appeared in a report by Goldstine and von Neumann as early as 1948.
Sorting algorithmIn computer science, a sorting algorithm is an algorithm that puts elements of a list into an order. The most frequently used orders are numerical order and lexicographical order, and either ascending or descending. Efficient sorting is important for optimizing the efficiency of other algorithms (such as search and merge algorithms) that require input data to be in sorted lists. Sorting is also often useful for canonicalizing data and for producing human-readable output.
Radix sortIn computer science, radix sort is a non-comparative sorting algorithm. It avoids comparison by creating and distributing elements into buckets according to their radix. For elements with more than one significant digit, this bucketing process is repeated for each digit, while preserving the ordering of the prior step, until all digits have been considered. For this reason, radix sort has also been called bucket sort and digital sort. Radix sort can be applied to data that can be sorted lexicographically, be they integers, words, punch cards, playing cards, or the mail.
External sortingExternal sorting is a class of sorting algorithms that can handle massive amounts of data. External sorting is required when the data being sorted do not fit into the main memory of a computing device (usually RAM) and instead they must reside in the slower external memory, usually a disk drive. Thus, external sorting algorithms are external memory algorithms and thus applicable in the external memory model of computation. External sorting algorithms generally fall into two types, distribution sorting, which resembles quicksort, and external merge sort, which resembles merge sort.
Sorting networkIn computer science, comparator networks are abstract devices built up of a fixed number of "wires", carrying values, and comparator modules that connect pairs of wires, swapping the values on the wires if they are not in a desired order. Such networks are typically designed to perform sorting on fixed numbers of values, in which case they are called sorting networks. Sorting networks differ from general comparison sorts in that they are not capable of handling arbitrarily large inputs, and in that their sequence of comparisons is set in advance, regardless of the outcome of previous comparisons.
Bubble sortBubble sort, sometimes referred to as sinking sort, is a simple sorting algorithm that repeatedly steps through the input list element by element, comparing the current element with the one after it, swapping their values if needed. These passes through the list are repeated until no swaps had to be performed during a pass, meaning that the list has become fully sorted. The algorithm, which is a comparison sort, is named for the way the larger elements "bubble" up to the top of the list.
Paper-based microfluidicsPaper-based microfluidics are microfluidic devices that consist of a series of hydrophilic cellulose or nitrocellulose fibers that transport fluid from an inlet through the porous medium to a desired outlet or region of the device, by means of capillary action. This technology builds on the conventional lateral flow test which is capable of detecting many infectious agents and chemical contaminants. The main advantage of this is that it is largely a passively controlled device unlike more complex microfluidic devices.
Counting sortIn computer science, counting sort is an algorithm for sorting a collection of objects according to keys that are small positive integers; that is, it is an integer sorting algorithm. It operates by counting the number of objects that possess distinct key values, and applying prefix sum on those counts to determine the positions of each key value in the output sequence. Its running time is linear in the number of items and the difference between the maximum key value and the minimum key value, so it is only suitable for direct use in situations where the variation in keys is not significantly greater than the number of items.
Potassium channelPotassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly (up to the diffusion rate of K+ ions in bulk water) and selectively (excluding, most notably, sodium despite the sub-angstrom difference in ionic radius).
Calcium channelA calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, although there are also ligand-gated calcium channels. The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated. voltage-gated calcium channel the receptor-operated calcium channels (in vasoconstriction) P2X receptors L-type calcium channel blockers are used to treat hypertension.
Ion channelIon channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, the other being ion transporters.
Chloride channelChloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration in vivo is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels (e.g., the CaCC families) have been characterized in humans. Voltage-gated chloride channels perform numerous crucial physiological and cellular functions, such as controlling pH, volume homeostasis, transporting organic solutes, regulating cell migration, proliferation, and differentiation.
Lab-on-a-chipA lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids.
