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Lecture

Mechanobiology: Cell Clusters

In course

ME-480: Mechanobiology: how mechanics regulate life

The objective of this course is to expose students to the fundamentals of mechanobiology. We will highlight the technologies that enable the study of living systems including mechanical manipulation and characterization, along with computational modeling f ...

Description

This lecture explores methods like AFM, tweezers, and traction force microscopy to measure cell mechanics. It delves into the use of silicone rubber and polyacrylamide substrates, discussing the visualization of traction forces and the implications of substrate stiffness on cellular behavior. The lecture also covers the mechanics of cell clusters, including the role of natural ECM, polyacrylamide hydrogels, and collagen gels. Additionally, it discusses super-resolved traction force microscopy, epithelial tissue mechanics basics, actomyosin structures, cell movements, experimental methods, mechanical waves, substrate stiffness, and models for studying cell behavior.

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Instructors (2)

Mahmut Selman Sakar

Alexandre Louis André Persat

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Related concepts (32)

Mechanical wave

In physics, a mechanical wave is a wave that is an oscillation of matter, and therefore transfers energy through a medium. While waves can move over long distances, the movement of the medium of transmission—the material—is limited. Therefore, the oscillating material does not move far from its initial equilibrium position. Mechanical waves can be produced only in media which possess elasticity and inertia. There are three types of mechanical waves: transverse waves, longitudinal waves, and surface waves.

Surface wave

In physics, a surface wave is a mechanical wave that propagates along the interface between differing media. A common example is gravity waves along the surface of liquids, such as ocean waves. Gravity waves can also occur within liquids, at the interface between two fluids with different densities. Elastic surface waves can travel along the surface of solids, such as Rayleigh or Love waves. Electromagnetic waves can also propagate as "surface waves" in that they can be guided along with a refractive index gradient or along an interface between two media having different dielectric constants.

Wave

In physics, mathematics, engineering, and related fields, a wave is a propagating dynamic disturbance (change from equilibrium) of one or more quantities. Waves can be periodic, in which case those quantities oscillate repeatedly about an equilibrium (resting) value at some frequency. When the entire waveform moves in one direction, it is said to be a traveling wave; by contrast, a pair of superimposed periodic waves traveling in opposite directions makes a standing wave.

Longitudinal wave

Longitudinal waves are waves in which the vibration of the medium is parallel to the direction the wave travels and displacement of the medium is in the same (or opposite) direction of the wave propagation. Mechanical longitudinal waves are also called compressional or compression waves, because they produce compression and rarefaction when traveling through a medium, and pressure waves, because they produce increases and decreases in pressure.

Seismic wave

A seismic wave is a mechanical wave of acoustic energy that travels through the Earth or another planetary body. It can result from an earthquake (or generally, a quake), volcanic eruption, magma movement, a large landslide, and a large man-made explosion that produces low-frequency acoustic energy. Seismic waves are studied by seismologists, who record the waves using seismometers, hydrophones (in water), or accelerometers.

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