Adaptive design (medicine)In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs) that are static in their protocol and do not modify any parameters until the trial is completed.
Algorithmic paradigmAn algorithmic paradigm or algorithm design paradigm is a generic model or framework which underlies the design of a class of algorithms. An algorithmic paradigm is an abstraction higher than the notion of an algorithm, just as an algorithm is an abstraction higher than a computer program. Backtracking Branch and bound Brute-force search Divide and conquer Dynamic programming Greedy algorithm Recursion Prune and search Kernelization Iterative compression Sweep line algorithms Rotating calipers Randomized i
Graph theoryIn mathematics, graph theory is the study of graphs, which are mathematical structures used to model pairwise relations between objects. A graph in this context is made up of vertices (also called nodes or points) which are connected by edges (also called links or lines). A distinction is made between undirected graphs, where edges link two vertices symmetrically, and directed graphs, where edges link two vertices asymmetrically. Graphs are one of the principal objects of study in discrete mathematics.
Matching in hypergraphsIn graph theory, a matching in a hypergraph is a set of hyperedges, in which every two hyperedges are disjoint. It is an extension of the notion of matching in a graph. Recall that a hypergraph H is a pair (V, E), where V is a set of vertices and E is a set of subsets of V called hyperedges. Each hyperedge may contain one or more vertices. A matching in H is a subset M of E, such that every two hyperedges e_1 and e_2 in M have an empty intersection (have no vertex in common).
Stable marriage problemIn mathematics, economics, and computer science, the stable marriage problem (also stable matching problem or SMP) is the problem of finding a stable matching between two equally sized sets of elements given an ordering of preferences for each element. A matching is a bijection from the elements of one set to the elements of the other set. A matching is not stable if: In other words, a matching is stable when there does not exist any pair (A, B) which both prefer each other to their current partner under the matching.
DataIn common usage and statistics, data (USˈdætə; UKˈdeɪtə) is a collection of discrete or continuous values that convey information, describing the quantity, quality, fact, statistics, other basic units of meaning, or simply sequences of symbols that may be further interpreted formally. A datum is an individual value in a collection of data. Data is usually organized into structures such as tables that provide additional context and meaning, and which may themselves be used as data in larger structures.
Approximation algorithmIn computer science and operations research, approximation algorithms are efficient algorithms that find approximate solutions to optimization problems (in particular NP-hard problems) with provable guarantees on the distance of the returned solution to the optimal one. Approximation algorithms naturally arise in the field of theoretical computer science as a consequence of the widely believed P ≠ NP conjecture. Under this conjecture, a wide class of optimization problems cannot be solved exactly in polynomial time.
Total coloringIn graph theory, total coloring is a type of graph coloring on the vertices and edges of a graph. When used without any qualification, a total coloring is always assumed to be proper in the sense that no adjacent edges, no adjacent vertices and no edge and either endvertex are assigned the same color. The total chromatic number χ′′(G) of a graph G is the fewest colors needed in any total coloring of G.
Big dataBig data primarily refers to data sets that are too large or complex to be dealt with by traditional data-processing application software. Data with many entries (rows) offer greater statistical power, while data with higher complexity (more attributes or columns) may lead to a higher false discovery rate. Though used sometimes loosely partly because of a lack of formal definition, the interpretation that seems to best describe big data is the one associated with a large body of information that we could not comprehend when used only in smaller amounts.
List edge-coloringIn mathematics, list edge-coloring is a type of graph coloring that combines list coloring and edge coloring. An instance of a list edge-coloring problem consists of a graph together with a list of allowed colors for each edge. A list edge-coloring is a choice of a color for each edge, from its list of allowed colors; a coloring is proper if no two adjacent edges receive the same color. A graph G is k-edge-choosable if every instance of list edge-coloring that has G as its underlying graph and that provides at least k allowed colors for each edge of G has a proper coloring.
Fractional coloringFractional coloring is a topic in a young branch of graph theory known as fractional graph theory. It is a generalization of ordinary graph coloring. In a traditional graph coloring, each vertex in a graph is assigned some color, and adjacent vertices — those connected by edges — must be assigned different colors. In a fractional coloring however, a set of colors is assigned to each vertex of a graph. The requirement about adjacent vertices still holds, so if two vertices are joined by an edge, they must have no colors in common.
Maximum cardinality matchingMaximum cardinality matching is a fundamental problem in graph theory. We are given a graph G, and the goal is to find a matching containing as many edges as possible; that is, a maximum cardinality subset of the edges such that each vertex is adjacent to at most one edge of the subset. As each edge will cover exactly two vertices, this problem is equivalent to the task of finding a matching that covers as many vertices as possible.
