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Lecture

Neuromodulation SoC: Brain-State Classifier & Neurostimulation

In course

EE-320: Analog IC design

Introduction to the design of analog CMOS integrated circuits at the transistor level. Understanding and design of basic structures. ...

Description

This lecture covers the design of a neuromodulation system for deep brain stimulation, including a frontend IC and a DSP IC. It focuses on a chopper-stabilized capacitive-coupled instrumentation amplifier, a BrainForest classifier, and a neuromodulation SoC with an 8-channel noise-shaping SAR ADC array. The system aims to accurately determine the optimal moment for neuromodulation efficacy, such as before the onset of a seizure in epilepsy, and supports closed-loop neuromodulation through an on-chip electrical neurostimulator.

Instructor

Mahsa Shoaran

Official source

Related concepts (32)

Operational amplifier

An operational amplifier (often op amp or opamp) is a DC-coupled high-gain electronic voltage amplifier with a differential input and, usually, a single-ended output. In this configuration, an op amp produces an output potential (relative to circuit ground) that is typically 100,000 times larger than the potential difference between its input terminals. The operational amplifier traces its origin and name to analog computers, where they were used to perform mathematical operations in linear, non-linear, and frequency-dependent circuits.

Neurostimulation

Neurostimulation is the purposeful modulation of the nervous system's activity using invasive (e.g. microelectrodes) or non-invasive means (e.g. transcranial magnetic stimulation or transcranial electric stimulation, tES, such as tDCS or transcranial alternating current stimulation, tACS). Neurostimulation usually refers to the electromagnetic approaches to neuromodulation.

Instrumentation amplifier

An instrumentation amplifier (sometimes shorthanded as in-amp or InAmp) is a type of differential amplifier that has been outfitted with input buffer amplifiers, which eliminate the need for input impedance matching and thus make the amplifier particularly suitable for use in measurement and test equipment. Additional characteristics include very low DC offset, low drift, low noise, very high open-loop gain, very high common-mode rejection ratio, and very high input impedances.

Amplifier

An amplifier, electronic amplifier or (informally) amp is an electronic device that can increase the magnitude of a signal (a time-varying voltage or current). It is a two-port electronic circuit that uses electric power from a power supply to increase the amplitude (magnitude of the voltage or current) of a signal applied to its input terminals, producing a proportionally greater amplitude signal at its output. The amount of amplification provided by an amplifier is measured by its gain: the ratio of output voltage, current, or power to input.

Neuromodulation (medicine)

Neuromodulation is "the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body". It is carried out to normalize – or modulate – nervous tissue function. Neuromodulation is an evolving therapy that can involve a range of electromagnetic stimuli such as a magnetic field (rTMS), an electric current, or a drug instilled directly in the subdural space (intrathecal drug delivery).

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