Lecture

Mechanobiology of Biofilms

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In course

ME-480: Mechanobiology: how mechanics regulate life

The objective of this course is to expose students to the fundamentals of mechanobiology. We will highlight the technologies that enable the study of living systems including mechanical manipulation and characterization, along with computational modeling f ...

Description

This lecture explores the mechanobiology of biofilms, focusing on the discovery of mechanically-activated Piezo channels and their essential role in linking mechanical forces to cellular responses. It delves into the impact of Piezo channels on various physiological processes, such as red blood cell volume regulation and lung inflation-induced apnoea. The lecture also discusses the architecture of biofilms, the advantages of living in a biofilm, and the coordination of matrix production in Vibrio cholerae biofilms. Furthermore, it examines the mechanical properties of biofilm matrix components, pressure sensing in biofilms, and the deformation dynamics of biofilms on soft substrates.

Instructors (2)

Mahmut Selman Sakar

Expertise robotics, mechanobiology, microtechnology, smart materials, biomedical devices Teaching & PhD PhD Students Lorenzo Francesco John Noseda, Nikita Norkin, Elif Ezgi Inan, Houman Javaheri, Mehdi Ali Gadiri, Julian Leon Raub, Junsun Hwang Past EPFL PhD Students Erik Mailand, Raquel Filipa Penacho Parreira, Murat Kaynak, Lucio Pancaldi-Giubbini, Fazil Emre Uslu, Matthias Rüegg, Ece Özelçi, Emilie Vuille-Dit-Bille Past EPFL PhD Students as codirector Laura Joan Hermans, Sourabh Monnappa Kuppanda Jafri

Alexandre Louis André Persat

Expertise bacterial biophysics and bioengineeringmicrofluidicscellular biomechanics Teaching & PhD PhD Students Jann Lukas Ledergerber, Dea Mariette Müller, Marin Paul Geoffroy Marie Ollagnon, Han-Yi Huang, Alice Pellegrino, Shiro Otaki, Chia-Ni Tsai, Po-Long Hsiao Past EPFL PhD Students Lorenzo Anton-Louis Talà, Xavier Pierrat, Tamara Rossy, Alice Cont, Jeremy Wong, Sourabh Monnappa Kuppanda Jafri, Tania Distler Past EPFL PhD Students as codirector Gabriele Gambardella Courses Fluid mechanics (for SV)

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Related concepts (32)

Matrix (mathematics)

In mathematics, a matrix (plural matrices) is a rectangular array or table of numbers, symbols, or expressions, arranged in rows and columns, which is used to represent a mathematical object or a property of such an object. For example, is a matrix with two rows and three columns. This is often referred to as a "two by three matrix", a " matrix", or a matrix of dimension . Without further specifications, matrices represent linear maps, and allow explicit computations in linear algebra.

Extracellular matrix

In biology, the extracellular matrix (ECM), also called intercellular matrix, is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.

Triangular matrix

In mathematics, a triangular matrix is a special kind of square matrix. A square matrix is called if all the entries above the main diagonal are zero. Similarly, a square matrix is called if all the entries below the main diagonal are zero. Because matrix equations with triangular matrices are easier to solve, they are very important in numerical analysis. By the LU decomposition algorithm, an invertible matrix may be written as the product of a lower triangular matrix L and an upper triangular matrix U if and only if all its leading principal minors are non-zero.

Stenotrophomonas maltophilia

Stenotrophomonas maltophilia is an aerobic, nonfermentative, Gram-negative bacterium. It is an uncommon bacterium and human infection is difficult to treat. Initially classified as Bacterium bookeri, then renamed Pseudomonas maltophilia, S. maltophilia was also grouped in the genus Xanthomonas before eventually becoming the type species of the genus Stenotrophomonas in 1993. S. maltophilia is slightly smaller (0.7–1.8 × 0.4–0.7 μm) than other members of the genus.

Transformation matrix

In linear algebra, linear transformations can be represented by matrices. If is a linear transformation mapping to and is a column vector with entries, then for some matrix , called the transformation matrix of . Note that has rows and columns, whereas the transformation is from to . There are alternative expressions of transformation matrices involving row vectors that are preferred by some authors. Matrices allow arbitrary linear transformations to be displayed in a consistent format, suitable for computation.

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