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Lecture

Cancer Biology: Base Excision Repair

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DNA Repair Mechanisms

Explores DNA repair mechanisms, focusing on BER and NER, cellular responses to DNA damage, and genetic disorders impacting DNA repair and cancer susceptibility.

Mutations and Cancer: The Role of P53 and HPV

Covers mutations, the role of P53 in cancer, and HPV's impact on tumorigenesis.

Evading Growth Suppression: TGFB Signaling

Explores how cells evade growth suppression, focusing on TGFB signaling and the role of tumor suppressors like PTEN and p53.

Apoptosis: Regulation and Signaling

Explores apoptosis regulation, impact on tumors, survival signaling pathways, autophagy in cancer, and challenges in mTOR targeting.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, tumor suppressor genes, metastasis, and genetic alterations driving tumorigenesis.

DNA Damage and Repair

Covers DNA damage types, repair mechanisms, UV-induced damage, survival curves, NER deficiency consequences, tumor suppressor genes, and cancer prevention.

Biological effects of ionizing radiation MOOC: Fundamentals of Biomedical Imaging: Ultrasounds, X-ray, positron emission tomography (PET) and applications

Explores the biological effects of ionizing radiation and how tissues defend against damage.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, DNA repair, telomeres, viruses, cell cycle, stem cells, metastasis, and genetic instability.

DNA Structure and Function

Explores DNA structure, histone interactions, polymerase function, nucleosome organization, chromatin compaction, cell cycle phases, FISH analysis, and telomere structure.

DNA Damage Checkpoint

Explores the DNA damage checkpoint, cell cycle regulation, repair mechanisms, and key proteins involved.

Telomere damage response

Discusses the telomere damage response and the interplay between ATM and ATR kinases.

Genetic Mutations: Causes and Effects

Explores genetic mutations, chromosomal abnormalities, DNA repair, and disease implications.

Telomeres and Cancer

Explores telomeres' role in cancer biology, covering telomerase, replication problems, ALT pathway, and Nobel Prize-winning discoveries.

Replicative Immortality

Explores replicative immortality in cancer cells, focusing on telomere erosion, telomerase activity, and the role of p53 in maintaining genomic stability.

DNA Replication: Sister Chromatids Cohesion

Explores DNA replication in eukaryotes and the cohesion of sister chromatids.

DNA Replication and Cancer

Explores the link between DNA replication, DNA repair mechanisms, and cancer development.

Tumor Suppressor p53

Explores the tumor suppressor gene p53, its functions, regulation, and implications for cancer.

Genetic Instability: De Palma

Explores genetic instability in cancer, multi-step progression, repair mechanisms, and cancer stem cells.

Understanding Cancer Genetics

Explores genetic and epigenetic changes in cancer cells and the impact of carcinogens.