New Drug ApplicationThe Food and Drug Administration's (FDA) New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing. Some 30% or less of initial drug candidates proceed through the entire multi-year process of drug development, concluding with an approved NDA, if successful. The goals of the NDA are to provide enough information to permit FDA reviewers to establish the complete history of the candidate drug.
Function (mathematics)In mathematics, a function from a set X to a set Y assigns to each element of X exactly one element of Y. The set X is called the domain of the function and the set Y is called the codomain of the function. Functions were originally the idealization of how a varying quantity depends on another quantity. For example, the position of a planet is a function of time. Historically, the concept was elaborated with the infinitesimal calculus at the end of the 17th century, and, until the 19th century, the functions that were considered were differentiable (that is, they had a high degree of regularity).
Differentiable functionIn mathematics, a differentiable function of one real variable is a function whose derivative exists at each point in its domain. In other words, the graph of a differentiable function has a non-vertical tangent line at each interior point in its domain. A differentiable function is smooth (the function is locally well approximated as a linear function at each interior point) and does not contain any break, angle, or cusp. If x0 is an interior point in the domain of a function f, then f is said to be differentiable at x0 if the derivative exists.
Product (category theory)In , the product of two (or more) in a is a notion designed to capture the essence behind constructions in other areas of mathematics such as the Cartesian product of sets, the direct product of groups or rings, and the product of topological spaces. Essentially, the product of a family of objects is the "most general" object which admits a morphism to each of the given objects.
Limit (category theory)In , a branch of mathematics, the abstract notion of a limit captures the essential properties of universal constructions such as , and inverse limits. The of a colimit generalizes constructions such as disjoint unions, direct sums, coproducts, s and direct limits. Limits and colimits, like the strongly related notions of universal properties and adjoint functors, exist at a high level of abstraction. In order to understand them, it is helpful to first study the specific examples these concepts are meant to generalize.
Localization (commutative algebra)In commutative algebra and algebraic geometry, localization is a formal way to introduce the "denominators" to a given ring or module. That is, it introduces a new ring/module out of an existing ring/module R, so that it consists of fractions such that the denominator s belongs to a given subset S of R. If S is the set of the non-zero elements of an integral domain, then the localization is the field of fractions: this case generalizes the construction of the field of rational numbers from the ring of integers.
Universal (metaphysics)In metaphysics, a universal is what particular things have in common, namely characteristics or qualities. In other words, universals are repeatable or recurrent entities that can be instantiated or exemplified by many particular things. For example, suppose there are two chairs in a room, each of which is green. These two chairs both share the quality of "chairness", as well as greenness or the quality of being green; in other words, they share two "universals". There are three major kinds of qualities or characteristics: types or kinds (e.
AxiomAn axiom, postulate, or assumption is a statement that is taken to be true, to serve as a premise or starting point for further reasoning and arguments. The word comes from the Ancient Greek word ἀξίωμα (), meaning 'that which is thought worthy or fit' or 'that which commends itself as evident'. The precise definition varies across fields of study. In classic philosophy, an axiom is a statement that is so evident or well-established, that it is accepted without controversy or question.
ExistenceExistence is the ability of an entity to interact with reality. In philosophy, it refers to the ontological property of being. The term existence comes from Old French existence, from Medieval Latin existentia/exsistentia, from Latin existere, to come forth, be manifest, ex + sistere, to stand. Materialism holds that the only things that exist are matter and energy, that all things are composed of material, that all actions require energy, and that all phenomena (including consciousness) are the result of the interaction of matter.
Adjoint functorsIn mathematics, specifically , adjunction is a relationship that two functors may exhibit, intuitively corresponding to a weak form of equivalence between two related categories. Two functors that stand in this relationship are known as adjoint functors, one being the left adjoint and the other the right adjoint. Pairs of adjoint functors are ubiquitous in mathematics and often arise from constructions of "optimal solutions" to certain problems (i.e.
Universality (philosophy)In philosophy, universality or absolutism is the idea that universal facts exist and can be progressively discovered, as opposed to relativism, which asserts that all facts are relative to one's perspective. Absolutism and relativism have been explored at length in contemporary analytic philosophy. Also see Kantian and Platonist notions of "universal", which are considered by most philosophers to be separate notions. Moral universalism When used in the context of ethics, the meaning of universal refers to that which is true for "all similarly situated individuals".
Food coloringFood coloring, or color additive, is any dye, pigment, or substance that imparts color when it is added to food or drink. They come in many forms consisting of liquids, powders, gels, and pastes. Food coloring is used in both commercial food production and domestic cooking. Food colorants are also used in a variety of non-food applications, including cosmetics, pharmaceuticals, home craft projects, and medical devices. People associate certain colors with certain flavors, and the color of food can influence the perceived flavor in anything from candy to wine.
