Enzyme kineticsEnzyme kinetics is the study of the rates of enzyme-catalysed chemical reactions. In enzyme kinetics, the reaction rate is measured and the effects of varying the conditions of the reaction are investigated. Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or a modifier (inhibitor or activator) might affect the rate. An enzyme (E) is typically a protein molecule that promotes a reaction of another molecule, its substrate (S).
Enzyme catalysisEnzyme catalysis is the increase in the rate of a process by a biological molecule, an "enzyme". Most enzymes are proteins, and most such processes are chemical reactions. Within the enzyme, generally catalysis occurs at a localized site, called the active site. Most enzymes are made predominantly of proteins, either a single protein chain or many such chains in a multi-subunit complex. Enzymes often also incorporate non-protein components, such as metal ions or specialized organic molecules known as cofactor (e.
Computer fileIn computing, a computer file is a resource for recording data on a computer storage device, primarily identified by its . Just as words can be written on paper, so can data be written to a computer file. Files can be shared with and transferred between computers and mobile devices via removable media, networks, or the Internet. Different are designed for different purposes. A file may be designed to store an , a written message, a video, a program, or any wide variety of other kinds of data.
HistoryHistory (derived ) is the systematic study and documentation of the human past. The period of events before the invention of writing systems is considered prehistory. "History" is an umbrella term comprising past events as well as the memory, discovery, collection, organization, presentation, and interpretation of these events. Historians seek knowledge of the past using historical sources such as written documents, oral accounts, art and material artifacts, and ecological markers.
Intellectual historyIntellectual history (also the history of ideas) is the study of the history of human thought and of intellectuals, people who conceptualize, discuss, write about, and concern themselves with ideas. The investigative premise of intellectual history is that ideas do not develop in isolation from the thinkers who conceptualize and apply those ideas; thus the intellectual historian studies ideas in two contexts: (i) as abstract propositions for critical application; and (ii) in concrete terms of culture, life, and history.
Microsoft OfficeMicrosoft Office, or simply Office, is a discontinued family of client software, server software, and services developed by Microsoft. It was first announced by Bill Gates on August 1, 1988, at COMDEX in Las Vegas. Initially a marketing term for an office suite (bundled set of productivity applications), the first version of Office contained Microsoft Word, Microsoft Excel, and Microsoft PowerPoint. Over the years, Office applications have grown substantially closer with shared features such as a common spell checker, Object Linking and Embedding data integration and Visual Basic for Applications scripting language.
Heterogeneous catalysisHeterogeneous catalysis is catalysis where the phase of catalysts differs from that of the reactants or products. The process contrasts with homogeneous catalysis where the reactants, products and catalyst exist in the same phase. Phase distinguishes between not only solid, liquid, and gas components, but also immiscible mixtures (e.g. oil and water), or anywhere an interface is present. Heterogeneous catalysis typically involves solid phase catalysts and gas phase reactants.
Counterfactual historyCounterfactual history (also virtual history) is a form of historiography that attempts to answer the What if? questions that arise from counterfactual conditions. As a method of intellectual enquiry, counterfactual history explores history and historical incidents by extrapolating a timeline in which key historical events either did not occur or had an outcome different from the actual historical outcome. Counterfactual history seeks by "conjecturing on what did not happen, or what might have happened, in order to understand what did happen.
Clustered file systemA clustered file system is a which is shared by being simultaneously mounted on multiple servers. There are several approaches to clustering, most of which do not employ a clustered file system (only direct attached storage for each node). Clustered file systems can provide features like location-independent addressing and redundancy which improve reliability or reduce the complexity of the other parts of the cluster. Parallel file systems are a type of clustered file system that spread data across multiple storage nodes, usually for redundancy or performance.
Sign languageSign languages (also known as signed languages) are languages that use the visual-manual modality to convey meaning, instead of spoken words. Sign languages are expressed through manual articulation in combination with non-manual markers. Sign languages are full-fledged natural languages with their own grammar and lexicon. Sign languages are not universal and are usually not mutually intelligible, although there are also similarities among different sign languages.
EnzymeEnzymes (ˈɛnzaɪmz) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps.
Review articleA review article is an article that summarizes the current state of understanding on a topic within a certain discipline. A review article is generally considered a secondary source since it may analyze and discuss the method and conclusions in previously published studies. It resembles a survey article or, in news publishing, overview article, which also surveys and summarizes previously published primary and secondary sources, instead of reporting new facts and results.
Outlook.comOutlook.com, formerly named Hotmail, is a free webmail service that is part of the Microsoft 365 product family. It offers mail, calendaring, contacts, and tasks services. Founded in 1996 by Sabeer Bhatia and Jack Smith as Hotmail, it was acquired by Microsoft in 1997 for an estimated $400 million and relaunched as MSN Hotmail, later rebranded to Windows Live Hotmail as part of the Windows Live suite of products. Microsoft phased out Hotmail in October 2011, relaunching the service as Outlook.com in 2012.
Microsoft 365Microsoft 365 is a product family of productivity software, collaboration and cloud-based services owned by Microsoft. It encompasses online services such as Outlook.com, OneDrive, Microsoft Teams, programs formerly marketed under the name Microsoft Office (including applications such as Word, Excel, PowerPoint, and Outlook on Microsoft Windows, macOS, mobile devices, and on the web), enterprise products and services associated with these products such as Exchange Server, SharePoint, and Yammer.
Alternate historyAlternate history (also alternative history, allohistory, althist, or AH) is a subgenre of speculative fiction in which one or more historical events have occurred but are resolved differently than in actual history. As conjecture based upon historical fact, alternate history stories propose What if? scenarios about crucial events in human history, and present outcomes very different from the historical record. Some alternate histories are considered a subgenre of literary fiction, science fiction, or historical fiction.
MSNMSN (meaning Microsoft Network) is a web portal and related collection of Internet services and apps for Windows and mobile devices, provided by Microsoft and launched on August 24, 1995, alongside the release of Windows 95. The Microsoft Network was initially a subscription-based dial-up online service that later became an Internet service provider named MSN Dial-up. At the same time, the company launched a new web portal named Microsoft Internet Start and set it as the first default home page of Internet Explorer, its web browser.
File systemIn computing, a file system or filesystem (often abbreviated to fs) is a method and data structure that the operating system uses to control how data is stored and retrieved. Without a file system, data placed in a storage medium would be one large body of data with no way to tell where one piece of data stopped and the next began, or where any piece of data was located when it was time to retrieve it. By separating the data into pieces and giving each piece a name, the data are easily isolated and identified.
Systematic reviewA systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. A systematic review extracts and interprets data from published studies on the topic, then analyzes, describes, and summarizes interpretations into a refined conclusion. For example, a systematic review of randomized controlled trials is a way of summarizing and implementing evidence-based medicine.
COVID-19Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the virus SARS-CoV-2. The first known case was identified in Wuhan, China, in December 2019. The disease quickly spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‐19 are variable but often include fever, cough, headache, fatigue, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms.
Acid catalysisIn acid catalysis and base catalysis, a chemical reaction is catalyzed by an acid or a base. By Brønsted–Lowry acid–base theory, the acid is the proton (hydrogen ion, H+) donor and the base is the proton acceptor. Typical reactions catalyzed by proton transfer are esterifications and aldol reactions. In these reactions, the conjugate acid of the carbonyl group is a better electrophile than the neutral carbonyl group itself. Depending on the chemical species that act as the acid or base, catalytic mechanisms can be classified as either specific catalysis and general catalysis.
